Genetic and mechanistic basis for APOBEC3H alternative splicing, retrovirus restriction, and counteraction by HIV-1 protease

Human APOBEC3H (A3H) is a single-stranded DNA cytosine deaminase that inhibits HIV-1. Seven haplotypes (I–VII) and four splice variants (SV154/182/183/200) with differing antiviral activities and geographic distributions have been described, but the genetic and mechanistic basis for variant expressi...

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Detalles Bibliográficos
Autores principales: Ebrahimi, Diako, Richards, Christopher M., Carpenter, Michael A., Wang, Jiayi, Ikeda, Terumasa, Becker, Jordan T., Cheng, Adam Z., McCann, Jennifer L., Shaban, Nadine M., Salamango, Daniel J., Starrett, Gabriel J., Lingappa, Jairam R., Yong, Jeongsik, Brown, William L., Harris, Reuben S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175962/
https://www.ncbi.nlm.nih.gov/pubmed/30297863
http://dx.doi.org/10.1038/s41467-018-06594-3

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