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Borrowing From Nature: Biopolymers and Biocomposites as Smart Wound Care Materials

Wound repair is a complex and tightly regulated physiological process, involving the activation of various cell types throughout each subsequent step (homeostasis, inflammation, proliferation, and tissue remodeling). Any impairment within the correct sequence of the healing events could lead to chro...

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Autores principales: Suarato, Giulia, Bertorelli, Rosalia, Athanassiou, Athanassia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176001/
https://www.ncbi.nlm.nih.gov/pubmed/30333972
http://dx.doi.org/10.3389/fbioe.2018.00137
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author Suarato, Giulia
Bertorelli, Rosalia
Athanassiou, Athanassia
author_facet Suarato, Giulia
Bertorelli, Rosalia
Athanassiou, Athanassia
author_sort Suarato, Giulia
collection PubMed
description Wound repair is a complex and tightly regulated physiological process, involving the activation of various cell types throughout each subsequent step (homeostasis, inflammation, proliferation, and tissue remodeling). Any impairment within the correct sequence of the healing events could lead to chronic wounds, with potential effects on the patience quality of life, and consequent fallouts on the wound care management. Nature itself can be of inspiration for the development of fully biodegradable materials, presenting enhanced bioactive potentialities, and sustainability. Naturally-derived biopolymers are nowadays considered smart materials. They provide a versatile and tunable platform to design the appropriate extracellular matrix able to support tissue regeneration, while contrasting the onset of adverse events. In the past decades, fabrication of bioactive materials based on natural polymers, either of protein derivation or polysaccharide-based, has been extensively exploited to tackle wound-healing related problematics. However, in today's World the exclusive use of such materials is becoming an urgent challenge, to meet the demand of environmentally sustainable technologies to support our future needs, including applications in the fields of healthcare and wound management. In the following, we will briefly introduce the main physico-chemical and biological properties of some protein-based biopolymers and some naturally-derived polysaccharides. Moreover, we will present some of the recent technological processing and green fabrication approaches of novel composite materials based on these biopolymers, with particular attention on their applications in the skin tissue repair field. Lastly, we will highlight promising future perspectives for the development of a new generation of environmentally-friendly, naturally-derived, smart wound dressings.
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spelling pubmed-61760012018-10-17 Borrowing From Nature: Biopolymers and Biocomposites as Smart Wound Care Materials Suarato, Giulia Bertorelli, Rosalia Athanassiou, Athanassia Front Bioeng Biotechnol Bioengineering and Biotechnology Wound repair is a complex and tightly regulated physiological process, involving the activation of various cell types throughout each subsequent step (homeostasis, inflammation, proliferation, and tissue remodeling). Any impairment within the correct sequence of the healing events could lead to chronic wounds, with potential effects on the patience quality of life, and consequent fallouts on the wound care management. Nature itself can be of inspiration for the development of fully biodegradable materials, presenting enhanced bioactive potentialities, and sustainability. Naturally-derived biopolymers are nowadays considered smart materials. They provide a versatile and tunable platform to design the appropriate extracellular matrix able to support tissue regeneration, while contrasting the onset of adverse events. In the past decades, fabrication of bioactive materials based on natural polymers, either of protein derivation or polysaccharide-based, has been extensively exploited to tackle wound-healing related problematics. However, in today's World the exclusive use of such materials is becoming an urgent challenge, to meet the demand of environmentally sustainable technologies to support our future needs, including applications in the fields of healthcare and wound management. In the following, we will briefly introduce the main physico-chemical and biological properties of some protein-based biopolymers and some naturally-derived polysaccharides. Moreover, we will present some of the recent technological processing and green fabrication approaches of novel composite materials based on these biopolymers, with particular attention on their applications in the skin tissue repair field. Lastly, we will highlight promising future perspectives for the development of a new generation of environmentally-friendly, naturally-derived, smart wound dressings. Frontiers Media S.A. 2018-10-02 /pmc/articles/PMC6176001/ /pubmed/30333972 http://dx.doi.org/10.3389/fbioe.2018.00137 Text en Copyright © 2018 Suarato, Bertorelli and Athanassiou. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Suarato, Giulia
Bertorelli, Rosalia
Athanassiou, Athanassia
Borrowing From Nature: Biopolymers and Biocomposites as Smart Wound Care Materials
title Borrowing From Nature: Biopolymers and Biocomposites as Smart Wound Care Materials
title_full Borrowing From Nature: Biopolymers and Biocomposites as Smart Wound Care Materials
title_fullStr Borrowing From Nature: Biopolymers and Biocomposites as Smart Wound Care Materials
title_full_unstemmed Borrowing From Nature: Biopolymers and Biocomposites as Smart Wound Care Materials
title_short Borrowing From Nature: Biopolymers and Biocomposites as Smart Wound Care Materials
title_sort borrowing from nature: biopolymers and biocomposites as smart wound care materials
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176001/
https://www.ncbi.nlm.nih.gov/pubmed/30333972
http://dx.doi.org/10.3389/fbioe.2018.00137
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