Cargando…
Versatile Roles of LKB1 Kinase Signaling in Neural Development and Homeostasis
Kinase signaling pathways orchestrate a majority of cellular structures and functions across species. Liver kinase B1 (LKB1, also known as STK11 or Par-4) is a ubiquitously expressed master serine/threonine kinase that plays crucial roles in numerous cellular events, such as polarity control, prolif...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176002/ https://www.ncbi.nlm.nih.gov/pubmed/30333724 http://dx.doi.org/10.3389/fnmol.2018.00354 |
_version_ | 1783361616475062272 |
---|---|
author | Kuwako, Ken-ichiro Okano, Hideyuki |
author_facet | Kuwako, Ken-ichiro Okano, Hideyuki |
author_sort | Kuwako, Ken-ichiro |
collection | PubMed |
description | Kinase signaling pathways orchestrate a majority of cellular structures and functions across species. Liver kinase B1 (LKB1, also known as STK11 or Par-4) is a ubiquitously expressed master serine/threonine kinase that plays crucial roles in numerous cellular events, such as polarity control, proliferation, differentiation and energy homeostasis, in many types of cells by activating downstream kinases of the AMP-activated protein kinase (AMPK) subfamily members. In contrast to the accumulating evidence for LKB1 functions in nonneuronal tissues, its functions in the nervous system have been relatively less understood until recently. In the brain, LKB1 initially emerged as a principal regulator of axon/dendrite polarity in forebrain neurons. Thereafter, recent investigations have rapidly uncovered diverse and essential functions of LKB1 in the developing and mature nervous system, such as migration, neurite morphogenesis, myelination and the maintenance of neural integrity, demonstrating that LKB1 is also a multifunctional master kinase in the nervous system. In this review article, we summarize the expanding knowledge about the functional aspects of LKB1 signaling in neural development and homeostasis. |
format | Online Article Text |
id | pubmed-6176002 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-61760022018-10-17 Versatile Roles of LKB1 Kinase Signaling in Neural Development and Homeostasis Kuwako, Ken-ichiro Okano, Hideyuki Front Mol Neurosci Neuroscience Kinase signaling pathways orchestrate a majority of cellular structures and functions across species. Liver kinase B1 (LKB1, also known as STK11 or Par-4) is a ubiquitously expressed master serine/threonine kinase that plays crucial roles in numerous cellular events, such as polarity control, proliferation, differentiation and energy homeostasis, in many types of cells by activating downstream kinases of the AMP-activated protein kinase (AMPK) subfamily members. In contrast to the accumulating evidence for LKB1 functions in nonneuronal tissues, its functions in the nervous system have been relatively less understood until recently. In the brain, LKB1 initially emerged as a principal regulator of axon/dendrite polarity in forebrain neurons. Thereafter, recent investigations have rapidly uncovered diverse and essential functions of LKB1 in the developing and mature nervous system, such as migration, neurite morphogenesis, myelination and the maintenance of neural integrity, demonstrating that LKB1 is also a multifunctional master kinase in the nervous system. In this review article, we summarize the expanding knowledge about the functional aspects of LKB1 signaling in neural development and homeostasis. Frontiers Media S.A. 2018-10-02 /pmc/articles/PMC6176002/ /pubmed/30333724 http://dx.doi.org/10.3389/fnmol.2018.00354 Text en Copyright © 2018 Kuwako and Okano. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Kuwako, Ken-ichiro Okano, Hideyuki Versatile Roles of LKB1 Kinase Signaling in Neural Development and Homeostasis |
title | Versatile Roles of LKB1 Kinase Signaling in Neural Development and Homeostasis |
title_full | Versatile Roles of LKB1 Kinase Signaling in Neural Development and Homeostasis |
title_fullStr | Versatile Roles of LKB1 Kinase Signaling in Neural Development and Homeostasis |
title_full_unstemmed | Versatile Roles of LKB1 Kinase Signaling in Neural Development and Homeostasis |
title_short | Versatile Roles of LKB1 Kinase Signaling in Neural Development and Homeostasis |
title_sort | versatile roles of lkb1 kinase signaling in neural development and homeostasis |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176002/ https://www.ncbi.nlm.nih.gov/pubmed/30333724 http://dx.doi.org/10.3389/fnmol.2018.00354 |
work_keys_str_mv | AT kuwakokenichiro versatilerolesoflkb1kinasesignalinginneuraldevelopmentandhomeostasis AT okanohideyuki versatilerolesoflkb1kinasesignalinginneuraldevelopmentandhomeostasis |