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Versatile Roles of LKB1 Kinase Signaling in Neural Development and Homeostasis

Kinase signaling pathways orchestrate a majority of cellular structures and functions across species. Liver kinase B1 (LKB1, also known as STK11 or Par-4) is a ubiquitously expressed master serine/threonine kinase that plays crucial roles in numerous cellular events, such as polarity control, prolif...

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Autores principales: Kuwako, Ken-ichiro, Okano, Hideyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176002/
https://www.ncbi.nlm.nih.gov/pubmed/30333724
http://dx.doi.org/10.3389/fnmol.2018.00354
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author Kuwako, Ken-ichiro
Okano, Hideyuki
author_facet Kuwako, Ken-ichiro
Okano, Hideyuki
author_sort Kuwako, Ken-ichiro
collection PubMed
description Kinase signaling pathways orchestrate a majority of cellular structures and functions across species. Liver kinase B1 (LKB1, also known as STK11 or Par-4) is a ubiquitously expressed master serine/threonine kinase that plays crucial roles in numerous cellular events, such as polarity control, proliferation, differentiation and energy homeostasis, in many types of cells by activating downstream kinases of the AMP-activated protein kinase (AMPK) subfamily members. In contrast to the accumulating evidence for LKB1 functions in nonneuronal tissues, its functions in the nervous system have been relatively less understood until recently. In the brain, LKB1 initially emerged as a principal regulator of axon/dendrite polarity in forebrain neurons. Thereafter, recent investigations have rapidly uncovered diverse and essential functions of LKB1 in the developing and mature nervous system, such as migration, neurite morphogenesis, myelination and the maintenance of neural integrity, demonstrating that LKB1 is also a multifunctional master kinase in the nervous system. In this review article, we summarize the expanding knowledge about the functional aspects of LKB1 signaling in neural development and homeostasis.
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spelling pubmed-61760022018-10-17 Versatile Roles of LKB1 Kinase Signaling in Neural Development and Homeostasis Kuwako, Ken-ichiro Okano, Hideyuki Front Mol Neurosci Neuroscience Kinase signaling pathways orchestrate a majority of cellular structures and functions across species. Liver kinase B1 (LKB1, also known as STK11 or Par-4) is a ubiquitously expressed master serine/threonine kinase that plays crucial roles in numerous cellular events, such as polarity control, proliferation, differentiation and energy homeostasis, in many types of cells by activating downstream kinases of the AMP-activated protein kinase (AMPK) subfamily members. In contrast to the accumulating evidence for LKB1 functions in nonneuronal tissues, its functions in the nervous system have been relatively less understood until recently. In the brain, LKB1 initially emerged as a principal regulator of axon/dendrite polarity in forebrain neurons. Thereafter, recent investigations have rapidly uncovered diverse and essential functions of LKB1 in the developing and mature nervous system, such as migration, neurite morphogenesis, myelination and the maintenance of neural integrity, demonstrating that LKB1 is also a multifunctional master kinase in the nervous system. In this review article, we summarize the expanding knowledge about the functional aspects of LKB1 signaling in neural development and homeostasis. Frontiers Media S.A. 2018-10-02 /pmc/articles/PMC6176002/ /pubmed/30333724 http://dx.doi.org/10.3389/fnmol.2018.00354 Text en Copyright © 2018 Kuwako and Okano. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Kuwako, Ken-ichiro
Okano, Hideyuki
Versatile Roles of LKB1 Kinase Signaling in Neural Development and Homeostasis
title Versatile Roles of LKB1 Kinase Signaling in Neural Development and Homeostasis
title_full Versatile Roles of LKB1 Kinase Signaling in Neural Development and Homeostasis
title_fullStr Versatile Roles of LKB1 Kinase Signaling in Neural Development and Homeostasis
title_full_unstemmed Versatile Roles of LKB1 Kinase Signaling in Neural Development and Homeostasis
title_short Versatile Roles of LKB1 Kinase Signaling in Neural Development and Homeostasis
title_sort versatile roles of lkb1 kinase signaling in neural development and homeostasis
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176002/
https://www.ncbi.nlm.nih.gov/pubmed/30333724
http://dx.doi.org/10.3389/fnmol.2018.00354
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