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BDNF Val66Met Polymorphism and Gamma Band Disruption in Resting State Brain Functional Connectivity: A Magnetoencephalography Study in Cognitively Intact Older Females
The pathophysiological processes undermining brain functioning decades before the onset of the clinical symptoms associated with dementia are still not well understood. Several heritability studies have reported that the Brain Derived Neurotrophic Factor (BDNF) Val66Met genetic polymorphism could co...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176075/ https://www.ncbi.nlm.nih.gov/pubmed/30333719 http://dx.doi.org/10.3389/fnins.2018.00684 |
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author | Rodríguez-Rojo, Inmaculada C. Cuesta, Pablo López, María Eugenia de Frutos-Lucas, Jaisalmer Bruña, Ricardo Pereda, Ernesto Barabash, Ana Montejo, Pedro Montenegro-Peña, Mercedes Marcos, Alberto López-Higes, Ramón Fernández, Alberto Maestú, Fernando |
author_facet | Rodríguez-Rojo, Inmaculada C. Cuesta, Pablo López, María Eugenia de Frutos-Lucas, Jaisalmer Bruña, Ricardo Pereda, Ernesto Barabash, Ana Montejo, Pedro Montenegro-Peña, Mercedes Marcos, Alberto López-Higes, Ramón Fernández, Alberto Maestú, Fernando |
author_sort | Rodríguez-Rojo, Inmaculada C. |
collection | PubMed |
description | The pathophysiological processes undermining brain functioning decades before the onset of the clinical symptoms associated with dementia are still not well understood. Several heritability studies have reported that the Brain Derived Neurotrophic Factor (BDNF) Val66Met genetic polymorphism could contribute to the acceleration of cognitive decline in aging. This mutation may affect brain functional connectivity (FC), especially in those who are carriers of the BDNF Met allele. The aim of this work was to explore the influence of the BDNF Val66Met polymorphism in whole brain eyes-closed, resting-state magnetoencephalography (MEG) FC in a sample of 36 cognitively intact (CI) older females. All of them were ε3ε3 homozygotes for the apolipoprotein E (APOE) gene and were divided into two subgroups according to the presence of the Met allele: Val/Met group (n = 16) and Val/Val group (n = 20). They did not differ in age, years of education, Mini-Mental State Examination scores, or normalized hippocampal volumes. Our results showed reduced antero-posterior gamma band FC within the Val/Met genetic risk group, which may be caused by a GABAergic network impairment. Despite the lack of cognitive decline, these results might suggest a selective brain network vulnerability due to the carriage of the BDNF Met allele, which is linked to a potential progression to dementia. This neurophysiological signature, as tracked with MEG FC, indicates that age-related brain functioning changes could be mediated by the influence of particular genetic risk factors. |
format | Online Article Text |
id | pubmed-6176075 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-61760752018-10-17 BDNF Val66Met Polymorphism and Gamma Band Disruption in Resting State Brain Functional Connectivity: A Magnetoencephalography Study in Cognitively Intact Older Females Rodríguez-Rojo, Inmaculada C. Cuesta, Pablo López, María Eugenia de Frutos-Lucas, Jaisalmer Bruña, Ricardo Pereda, Ernesto Barabash, Ana Montejo, Pedro Montenegro-Peña, Mercedes Marcos, Alberto López-Higes, Ramón Fernández, Alberto Maestú, Fernando Front Neurosci Neuroscience The pathophysiological processes undermining brain functioning decades before the onset of the clinical symptoms associated with dementia are still not well understood. Several heritability studies have reported that the Brain Derived Neurotrophic Factor (BDNF) Val66Met genetic polymorphism could contribute to the acceleration of cognitive decline in aging. This mutation may affect brain functional connectivity (FC), especially in those who are carriers of the BDNF Met allele. The aim of this work was to explore the influence of the BDNF Val66Met polymorphism in whole brain eyes-closed, resting-state magnetoencephalography (MEG) FC in a sample of 36 cognitively intact (CI) older females. All of them were ε3ε3 homozygotes for the apolipoprotein E (APOE) gene and were divided into two subgroups according to the presence of the Met allele: Val/Met group (n = 16) and Val/Val group (n = 20). They did not differ in age, years of education, Mini-Mental State Examination scores, or normalized hippocampal volumes. Our results showed reduced antero-posterior gamma band FC within the Val/Met genetic risk group, which may be caused by a GABAergic network impairment. Despite the lack of cognitive decline, these results might suggest a selective brain network vulnerability due to the carriage of the BDNF Met allele, which is linked to a potential progression to dementia. This neurophysiological signature, as tracked with MEG FC, indicates that age-related brain functioning changes could be mediated by the influence of particular genetic risk factors. Frontiers Media S.A. 2018-10-02 /pmc/articles/PMC6176075/ /pubmed/30333719 http://dx.doi.org/10.3389/fnins.2018.00684 Text en Copyright © 2018 Rodríguez-Rojo, Cuesta, López, de Frutos-Lucas, Bruña, Pereda, Barabash, Montejo, Montenegro-Peña, Marcos, López-Higes, Fernández and Maestú. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Rodríguez-Rojo, Inmaculada C. Cuesta, Pablo López, María Eugenia de Frutos-Lucas, Jaisalmer Bruña, Ricardo Pereda, Ernesto Barabash, Ana Montejo, Pedro Montenegro-Peña, Mercedes Marcos, Alberto López-Higes, Ramón Fernández, Alberto Maestú, Fernando BDNF Val66Met Polymorphism and Gamma Band Disruption in Resting State Brain Functional Connectivity: A Magnetoencephalography Study in Cognitively Intact Older Females |
title | BDNF Val66Met Polymorphism and Gamma Band Disruption in Resting State Brain Functional Connectivity: A Magnetoencephalography Study in Cognitively Intact Older Females |
title_full | BDNF Val66Met Polymorphism and Gamma Band Disruption in Resting State Brain Functional Connectivity: A Magnetoencephalography Study in Cognitively Intact Older Females |
title_fullStr | BDNF Val66Met Polymorphism and Gamma Band Disruption in Resting State Brain Functional Connectivity: A Magnetoencephalography Study in Cognitively Intact Older Females |
title_full_unstemmed | BDNF Val66Met Polymorphism and Gamma Band Disruption in Resting State Brain Functional Connectivity: A Magnetoencephalography Study in Cognitively Intact Older Females |
title_short | BDNF Val66Met Polymorphism and Gamma Band Disruption in Resting State Brain Functional Connectivity: A Magnetoencephalography Study in Cognitively Intact Older Females |
title_sort | bdnf val66met polymorphism and gamma band disruption in resting state brain functional connectivity: a magnetoencephalography study in cognitively intact older females |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176075/ https://www.ncbi.nlm.nih.gov/pubmed/30333719 http://dx.doi.org/10.3389/fnins.2018.00684 |
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