Natural products targeting the p53-MDM2 pathway and mutant p53: Recent advances and implications in cancer medicine

The p53 tumor suppressor plays a major role in controlling the initiation and development of cancer by regulating cell cycle arrest, apoptosis, senescence, and DNA repair. The MDM2 oncogene is a major negative regulator of p53 that inhibits the activity of p53 and reduces its protein stability. MDM2...

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Detalles Bibliográficos
Autores principales: Qin, Jiang-Jiang, Li, Xin, Hunt, Courtney, Wang, Wei, Wang, Hui, Zhang, Ruiwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176154/
https://www.ncbi.nlm.nih.gov/pubmed/30320185
http://dx.doi.org/10.1016/j.gendis.2018.07.002

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