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Classical Hodgkin Lymphoma Presenting with Severe, Recurrent Hypothermic Episodes

We report a case presenting with recurrent episodes of severe hypothermia preceding the diagnosis of Hodgkin lymphoma. The episodes of hypothermia were accompanied by other symptoms of autonomic dysfunction, mainly hypotension, which could be caused by autonomic neuropathy as part of a paraneoplasti...

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Detalles Bibliográficos
Autores principales: Hansen, Jonas Juul, Beier Ommen, Hans, Gormsen, Lars Christian, d'Amore, Francesco Annibale, Hjørnet Kamper, Peter Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176302/
https://www.ncbi.nlm.nih.gov/pubmed/30356349
http://dx.doi.org/10.1155/2018/3726593
Descripción
Sumario:We report a case presenting with recurrent episodes of severe hypothermia preceding the diagnosis of Hodgkin lymphoma. The episodes of hypothermia were accompanied by other symptoms of autonomic dysfunction, mainly hypotension, which could be caused by autonomic neuropathy as part of a paraneoplastic syndrome. In comparison with previous reports describing an association between the presence of hypothermia and an adverse outcome, the present patient has responded well to lymphoma-specific treatment and is currently in an ongoing complete remission. Due to the peculiar cyclic pattern of the hypothermic episodes presented in this case, we hypothesize whether intermittent release of disease-related chemo- and cytokines could be a plausible pathogenetic explanation.