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Systemic Inflammation Characterizes Lack of Metabolic Health in Nonobese HIV-Infected Men

BACKGROUND: Increasing body mass index (BMI) is generally associated with loss of metabolic health, although some obese individuals remain metabolically healthy. Among nonobese men, HIV infection has been associated with a lower prevalence of metabolic health. METHODS: We conducted a cross-sectional...

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Autores principales: Monczor, Ana N., Li, Xiuhong, Palella, Frank J., Erlandson, Kristine M., Wiley, Dorothy, Kingsley, Lawrence A., Post, Wendy S., Jacobson, Lisa P., Brown, Todd T., Lake, Jordan E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176328/
https://www.ncbi.nlm.nih.gov/pubmed/30356397
http://dx.doi.org/10.1155/2018/5327361
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author Monczor, Ana N.
Li, Xiuhong
Palella, Frank J.
Erlandson, Kristine M.
Wiley, Dorothy
Kingsley, Lawrence A.
Post, Wendy S.
Jacobson, Lisa P.
Brown, Todd T.
Lake, Jordan E.
author_facet Monczor, Ana N.
Li, Xiuhong
Palella, Frank J.
Erlandson, Kristine M.
Wiley, Dorothy
Kingsley, Lawrence A.
Post, Wendy S.
Jacobson, Lisa P.
Brown, Todd T.
Lake, Jordan E.
author_sort Monczor, Ana N.
collection PubMed
description BACKGROUND: Increasing body mass index (BMI) is generally associated with loss of metabolic health, although some obese individuals remain metabolically healthy. Among nonobese men, HIV infection has been associated with a lower prevalence of metabolic health. METHODS: We conducted a cross-sectional analysis of 470 HIV-infected and 368 HIV-uninfected men enrolled in the Multicenter AIDS Cohort Study Cardiovascular substudy. Circulating biomarker levels were compared by BMI category and by HIV serostatus. Poisson regression with robust variance determined associations between metabolic health and circulating inflammatory biomarker levels after adjusting for factors previously associated with metabolic health. RESULTS: HIV-infected men were younger and less likely to be obese. Among HIV-infected, normal weight metabolically healthy men (compared to unhealthy) had significantly lower circulating levels of interleukin- (IL-) 6, soluble tumor necrosis factor receptors (sTNFR) I and II, and homeostatic model assessment of insulin resistance (HOMA-IR), higher adiponectin, less visceral fat, and more subcutaneous fat. Among HIV-uninfected normal weight men and obese men (regardless of HIV serostatus), metabolic health was associated only with higher levels of adiponectin, less visceral fat, and lower HOMA-IR values. In multivariate analyses restricted to HIV-infected men, lower hs-CRP, sTNFRI, sTNFRII, and HOMA-IR and higher adiponectin levels were associated with metabolic health. Additional adjustment for visceral adiposity did not alter results. CONCLUSIONS: Among HIV-infected normal weight men, metabolic health was associated with less systemic inflammation, a relationship that, among normal weight men, was unique to HIV+ men and did not exist among obese men of either HIV serostatus.
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spelling pubmed-61763282018-10-23 Systemic Inflammation Characterizes Lack of Metabolic Health in Nonobese HIV-Infected Men Monczor, Ana N. Li, Xiuhong Palella, Frank J. Erlandson, Kristine M. Wiley, Dorothy Kingsley, Lawrence A. Post, Wendy S. Jacobson, Lisa P. Brown, Todd T. Lake, Jordan E. Mediators Inflamm Research Article BACKGROUND: Increasing body mass index (BMI) is generally associated with loss of metabolic health, although some obese individuals remain metabolically healthy. Among nonobese men, HIV infection has been associated with a lower prevalence of metabolic health. METHODS: We conducted a cross-sectional analysis of 470 HIV-infected and 368 HIV-uninfected men enrolled in the Multicenter AIDS Cohort Study Cardiovascular substudy. Circulating biomarker levels were compared by BMI category and by HIV serostatus. Poisson regression with robust variance determined associations between metabolic health and circulating inflammatory biomarker levels after adjusting for factors previously associated with metabolic health. RESULTS: HIV-infected men were younger and less likely to be obese. Among HIV-infected, normal weight metabolically healthy men (compared to unhealthy) had significantly lower circulating levels of interleukin- (IL-) 6, soluble tumor necrosis factor receptors (sTNFR) I and II, and homeostatic model assessment of insulin resistance (HOMA-IR), higher adiponectin, less visceral fat, and more subcutaneous fat. Among HIV-uninfected normal weight men and obese men (regardless of HIV serostatus), metabolic health was associated only with higher levels of adiponectin, less visceral fat, and lower HOMA-IR values. In multivariate analyses restricted to HIV-infected men, lower hs-CRP, sTNFRI, sTNFRII, and HOMA-IR and higher adiponectin levels were associated with metabolic health. Additional adjustment for visceral adiposity did not alter results. CONCLUSIONS: Among HIV-infected normal weight men, metabolic health was associated with less systemic inflammation, a relationship that, among normal weight men, was unique to HIV+ men and did not exist among obese men of either HIV serostatus. Hindawi 2018-09-25 /pmc/articles/PMC6176328/ /pubmed/30356397 http://dx.doi.org/10.1155/2018/5327361 Text en Copyright © 2018 Ana N. Monczor et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Monczor, Ana N.
Li, Xiuhong
Palella, Frank J.
Erlandson, Kristine M.
Wiley, Dorothy
Kingsley, Lawrence A.
Post, Wendy S.
Jacobson, Lisa P.
Brown, Todd T.
Lake, Jordan E.
Systemic Inflammation Characterizes Lack of Metabolic Health in Nonobese HIV-Infected Men
title Systemic Inflammation Characterizes Lack of Metabolic Health in Nonobese HIV-Infected Men
title_full Systemic Inflammation Characterizes Lack of Metabolic Health in Nonobese HIV-Infected Men
title_fullStr Systemic Inflammation Characterizes Lack of Metabolic Health in Nonobese HIV-Infected Men
title_full_unstemmed Systemic Inflammation Characterizes Lack of Metabolic Health in Nonobese HIV-Infected Men
title_short Systemic Inflammation Characterizes Lack of Metabolic Health in Nonobese HIV-Infected Men
title_sort systemic inflammation characterizes lack of metabolic health in nonobese hiv-infected men
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176328/
https://www.ncbi.nlm.nih.gov/pubmed/30356397
http://dx.doi.org/10.1155/2018/5327361
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