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Fatal Septic Shock in a Patient with Hemophagocytic Lymphohistiocytosis Associated with an Infectious Mononucleosis
The authors describe the case of a young woman who developed a clinical pictures resembling a septic shock-related multiple organ dysfunction syndrome a couple of months after having been diagnosed suffering from a hemophagocytic lymphohistiocytosis associated with an infectious mononucleosis. Despi...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176343/ https://www.ncbi.nlm.nih.gov/pubmed/30356381 http://dx.doi.org/10.1155/2018/9756050 |
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author | Berlot, Giorgio Tomasini, Ariella Zandonà, Lorenzo Leonardo, Eugenio Bussani, Rossana Zarrillo, Nadia |
author_facet | Berlot, Giorgio Tomasini, Ariella Zandonà, Lorenzo Leonardo, Eugenio Bussani, Rossana Zarrillo, Nadia |
author_sort | Berlot, Giorgio |
collection | PubMed |
description | The authors describe the case of a young woman who developed a clinical pictures resembling a septic shock-related multiple organ dysfunction syndrome a couple of months after having been diagnosed suffering from a hemophagocytic lymphohistiocytosis associated with an infectious mononucleosis. Despite the aggressive treatment, which included antibiotics, vasopressors, IV immunoglobulins, and the use of an extracorporeal device aimed to remove mediators released both during sepsis and the cytokine storm determined by the hemophagocytic lymphohistiocytosis, the patient died. At the autopsy, an extremely uncommon aggressive lymphoma of Epstein-Barr virus-positive T-lymphocytes with systemic involvement was discovered. |
format | Online Article Text |
id | pubmed-6176343 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-61763432018-10-23 Fatal Septic Shock in a Patient with Hemophagocytic Lymphohistiocytosis Associated with an Infectious Mononucleosis Berlot, Giorgio Tomasini, Ariella Zandonà, Lorenzo Leonardo, Eugenio Bussani, Rossana Zarrillo, Nadia Case Rep Crit Care Case Report The authors describe the case of a young woman who developed a clinical pictures resembling a septic shock-related multiple organ dysfunction syndrome a couple of months after having been diagnosed suffering from a hemophagocytic lymphohistiocytosis associated with an infectious mononucleosis. Despite the aggressive treatment, which included antibiotics, vasopressors, IV immunoglobulins, and the use of an extracorporeal device aimed to remove mediators released both during sepsis and the cytokine storm determined by the hemophagocytic lymphohistiocytosis, the patient died. At the autopsy, an extremely uncommon aggressive lymphoma of Epstein-Barr virus-positive T-lymphocytes with systemic involvement was discovered. Hindawi 2018-09-25 /pmc/articles/PMC6176343/ /pubmed/30356381 http://dx.doi.org/10.1155/2018/9756050 Text en Copyright © 2018 Giorgio Berlot et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Berlot, Giorgio Tomasini, Ariella Zandonà, Lorenzo Leonardo, Eugenio Bussani, Rossana Zarrillo, Nadia Fatal Septic Shock in a Patient with Hemophagocytic Lymphohistiocytosis Associated with an Infectious Mononucleosis |
title | Fatal Septic Shock in a Patient with Hemophagocytic Lymphohistiocytosis Associated with an Infectious Mononucleosis |
title_full | Fatal Septic Shock in a Patient with Hemophagocytic Lymphohistiocytosis Associated with an Infectious Mononucleosis |
title_fullStr | Fatal Septic Shock in a Patient with Hemophagocytic Lymphohistiocytosis Associated with an Infectious Mononucleosis |
title_full_unstemmed | Fatal Septic Shock in a Patient with Hemophagocytic Lymphohistiocytosis Associated with an Infectious Mononucleosis |
title_short | Fatal Septic Shock in a Patient with Hemophagocytic Lymphohistiocytosis Associated with an Infectious Mononucleosis |
title_sort | fatal septic shock in a patient with hemophagocytic lymphohistiocytosis associated with an infectious mononucleosis |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176343/ https://www.ncbi.nlm.nih.gov/pubmed/30356381 http://dx.doi.org/10.1155/2018/9756050 |
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