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Fatal Septic Shock in a Patient with Hemophagocytic Lymphohistiocytosis Associated with an Infectious Mononucleosis

The authors describe the case of a young woman who developed a clinical pictures resembling a septic shock-related multiple organ dysfunction syndrome a couple of months after having been diagnosed suffering from a hemophagocytic lymphohistiocytosis associated with an infectious mononucleosis. Despi...

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Autores principales: Berlot, Giorgio, Tomasini, Ariella, Zandonà, Lorenzo, Leonardo, Eugenio, Bussani, Rossana, Zarrillo, Nadia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176343/
https://www.ncbi.nlm.nih.gov/pubmed/30356381
http://dx.doi.org/10.1155/2018/9756050
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author Berlot, Giorgio
Tomasini, Ariella
Zandonà, Lorenzo
Leonardo, Eugenio
Bussani, Rossana
Zarrillo, Nadia
author_facet Berlot, Giorgio
Tomasini, Ariella
Zandonà, Lorenzo
Leonardo, Eugenio
Bussani, Rossana
Zarrillo, Nadia
author_sort Berlot, Giorgio
collection PubMed
description The authors describe the case of a young woman who developed a clinical pictures resembling a septic shock-related multiple organ dysfunction syndrome a couple of months after having been diagnosed suffering from a hemophagocytic lymphohistiocytosis associated with an infectious mononucleosis. Despite the aggressive treatment, which included antibiotics, vasopressors, IV immunoglobulins, and the use of an extracorporeal device aimed to remove mediators released both during sepsis and the cytokine storm determined by the hemophagocytic lymphohistiocytosis, the patient died. At the autopsy, an extremely uncommon aggressive lymphoma of Epstein-Barr virus-positive T-lymphocytes with systemic involvement was discovered.
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spelling pubmed-61763432018-10-23 Fatal Septic Shock in a Patient with Hemophagocytic Lymphohistiocytosis Associated with an Infectious Mononucleosis Berlot, Giorgio Tomasini, Ariella Zandonà, Lorenzo Leonardo, Eugenio Bussani, Rossana Zarrillo, Nadia Case Rep Crit Care Case Report The authors describe the case of a young woman who developed a clinical pictures resembling a septic shock-related multiple organ dysfunction syndrome a couple of months after having been diagnosed suffering from a hemophagocytic lymphohistiocytosis associated with an infectious mononucleosis. Despite the aggressive treatment, which included antibiotics, vasopressors, IV immunoglobulins, and the use of an extracorporeal device aimed to remove mediators released both during sepsis and the cytokine storm determined by the hemophagocytic lymphohistiocytosis, the patient died. At the autopsy, an extremely uncommon aggressive lymphoma of Epstein-Barr virus-positive T-lymphocytes with systemic involvement was discovered. Hindawi 2018-09-25 /pmc/articles/PMC6176343/ /pubmed/30356381 http://dx.doi.org/10.1155/2018/9756050 Text en Copyright © 2018 Giorgio Berlot et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Berlot, Giorgio
Tomasini, Ariella
Zandonà, Lorenzo
Leonardo, Eugenio
Bussani, Rossana
Zarrillo, Nadia
Fatal Septic Shock in a Patient with Hemophagocytic Lymphohistiocytosis Associated with an Infectious Mononucleosis
title Fatal Septic Shock in a Patient with Hemophagocytic Lymphohistiocytosis Associated with an Infectious Mononucleosis
title_full Fatal Septic Shock in a Patient with Hemophagocytic Lymphohistiocytosis Associated with an Infectious Mononucleosis
title_fullStr Fatal Septic Shock in a Patient with Hemophagocytic Lymphohistiocytosis Associated with an Infectious Mononucleosis
title_full_unstemmed Fatal Septic Shock in a Patient with Hemophagocytic Lymphohistiocytosis Associated with an Infectious Mononucleosis
title_short Fatal Septic Shock in a Patient with Hemophagocytic Lymphohistiocytosis Associated with an Infectious Mononucleosis
title_sort fatal septic shock in a patient with hemophagocytic lymphohistiocytosis associated with an infectious mononucleosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176343/
https://www.ncbi.nlm.nih.gov/pubmed/30356381
http://dx.doi.org/10.1155/2018/9756050
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