Effect of anesthetic methods on postoperative CD3(+), CD4(+) and CD4(+)CD25(+) in patients with lung cancer undergoing radical operation

Effects of anesthesia methods on immune function in patients with lung cancer undergoing radical operation were investigated. A total of 122 patients undergoing radical resection of lung cancer who were treated in Zhejiang Cancer Hospital from September 2013 to April 2016 were randomly divided into the combined anesthesia group and the intravenous anesthesia group, with 61 cases in each group. The patients in the combined anesthesia group were given intravenous combined epidural anesthesia. Patients in the intravenous anesthesia group were given intravenous anesthesia. The change of CD3(+), CD4(+) and CD4(+)CD25(+) at time-point T0 (before anesthesia), T1 (the time of anesthesia), T2 (after operation), T3 (24 h after operation), T4 (72 h after operation) were compared between the two groups. The levels of CD3(+), CD4(+) and CD4(+)CD25(+) at T1, T2, T3 and T4 in the combined anesthesia group were higher than that in the intravenous anesthesia group (P<0.05). Αfter starting anesthesia, the levels of CD3(+), CD4(+) and CD4(+)CD25(+) began to decrease in both groups. The levels of CD3(+), CD4(+) and CD4(+)CD25(+) at T2 and T1 were lower than those at T0 (P<0.05). The levels of CD3(+), CD4(+) and CD4(+)CD25(+) at T2 were lower than T1 (P<0.05). After T3, the levels of CD3(+), CD4(+) and CD4(+)CD25(+) began to increase in both groups. Τhe levels of CD3(+), CD4(+) and CD4(+)CD25(+) at T3 and T4 were higher in both groups than those at T2 and T1 (P<0.05), and the levels of CD3(+), CD4(+) and CD4(+)CD25(+) at T4 were higher in both groups than those at T3, but the levels of CD3(+), CD4(+) and CD4(+)CD25(+) at T3 and T4 were lower than those at T0 (P<0.05). Intravenous combined epidural anesthesia can maintain a relatively stable immune function compared with simple intravenous anesthesia patients.