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Old muscle in young body: an aphorism describing the Chronic Fatigue Syndrome
The chronic fatigue syndrome (CFS) otherwise known as myalgic encephalomyelitis (ME), is a debilitating syndrome whose identification is very complex due to lack of precise diagnostic criteria. This pathology begins with limitations in duration and intensity of exercise and rapid onset of pain durin...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PAGEPress Publications, Pavia, Italy
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176399/ https://www.ncbi.nlm.nih.gov/pubmed/30344981 http://dx.doi.org/10.4081/ejtm.2018.7688 |
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author | Pietrangelo, Tiziana Fulle, Stefania Coscia, Francesco Gigliotti, Paola Virginia Fanò-Illic, Giorgio |
author_facet | Pietrangelo, Tiziana Fulle, Stefania Coscia, Francesco Gigliotti, Paola Virginia Fanò-Illic, Giorgio |
author_sort | Pietrangelo, Tiziana |
collection | PubMed |
description | The chronic fatigue syndrome (CFS) otherwise known as myalgic encephalomyelitis (ME), is a debilitating syndrome whose identification is very complex due to lack of precise diagnostic criteria. This pathology begins with limitations in duration and intensity of exercise and rapid onset of pain during physical activity. Its etiology is unknown, and symptoms are not limited to the muscles. Epidemiology is rather difficult to delimit, even if it affects mainly young (20-40 years), female subjects. The results of muscular research show some peculiarities that can justify what has been observed in vivo. In particular, 1. presence of oxidative damage of lipid component of biological membranes and DNA not compensated by the increase of the scavenger activity; 2. Excitation-Contraction (E-C) alteration with modification of Ca(2+) transport; 3. passage from slow to fast fiber phenotype; 4. inability to increase glucose uptake; 5. presence of mitochondrial dysfunction; and 6. genes expressed differentially (particularly those involved in energy production). The skeletal muscles of CFS / ME patients show a significant alteration of the oxidative balance due to mitochondrial alteration and of the fiber phenotype composition as shown in sarcopenic muscles of the elderly. Vice versa, the muscle catabolism does not appear to be involved in the onset of this syndrome. The data support the hypothesis that patients with CFS are subjected to some of the problems typical for muscle aging, which is probably related to disorders of muscle protein synthesis and biogenesis of mitochondria. Patients with CFS can benefit from an appropriate training program because no evidence suggests that physical exercise worsens symptoms. Type, intensity and duration of any physical activity that activates muscle contraction (including Electrical Stimulation) require further investigation even if it is known that non-exhaustive physical activity decreases painful symptomatology. |
format | Online Article Text |
id | pubmed-6176399 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | PAGEPress Publications, Pavia, Italy |
record_format | MEDLINE/PubMed |
spelling | pubmed-61763992018-10-19 Old muscle in young body: an aphorism describing the Chronic Fatigue Syndrome Pietrangelo, Tiziana Fulle, Stefania Coscia, Francesco Gigliotti, Paola Virginia Fanò-Illic, Giorgio Eur J Transl Myol Chronic Fatigue Syndrome / Myalgic Encephalomyelitis The chronic fatigue syndrome (CFS) otherwise known as myalgic encephalomyelitis (ME), is a debilitating syndrome whose identification is very complex due to lack of precise diagnostic criteria. This pathology begins with limitations in duration and intensity of exercise and rapid onset of pain during physical activity. Its etiology is unknown, and symptoms are not limited to the muscles. Epidemiology is rather difficult to delimit, even if it affects mainly young (20-40 years), female subjects. The results of muscular research show some peculiarities that can justify what has been observed in vivo. In particular, 1. presence of oxidative damage of lipid component of biological membranes and DNA not compensated by the increase of the scavenger activity; 2. Excitation-Contraction (E-C) alteration with modification of Ca(2+) transport; 3. passage from slow to fast fiber phenotype; 4. inability to increase glucose uptake; 5. presence of mitochondrial dysfunction; and 6. genes expressed differentially (particularly those involved in energy production). The skeletal muscles of CFS / ME patients show a significant alteration of the oxidative balance due to mitochondrial alteration and of the fiber phenotype composition as shown in sarcopenic muscles of the elderly. Vice versa, the muscle catabolism does not appear to be involved in the onset of this syndrome. The data support the hypothesis that patients with CFS are subjected to some of the problems typical for muscle aging, which is probably related to disorders of muscle protein synthesis and biogenesis of mitochondria. Patients with CFS can benefit from an appropriate training program because no evidence suggests that physical exercise worsens symptoms. Type, intensity and duration of any physical activity that activates muscle contraction (including Electrical Stimulation) require further investigation even if it is known that non-exhaustive physical activity decreases painful symptomatology. PAGEPress Publications, Pavia, Italy 2018-09-07 /pmc/articles/PMC6176399/ /pubmed/30344981 http://dx.doi.org/10.4081/ejtm.2018.7688 Text en http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License (by-nc 4.0) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Chronic Fatigue Syndrome / Myalgic Encephalomyelitis Pietrangelo, Tiziana Fulle, Stefania Coscia, Francesco Gigliotti, Paola Virginia Fanò-Illic, Giorgio Old muscle in young body: an aphorism describing the Chronic Fatigue Syndrome |
title | Old muscle in young body: an aphorism describing the Chronic Fatigue Syndrome |
title_full | Old muscle in young body: an aphorism describing the Chronic Fatigue Syndrome |
title_fullStr | Old muscle in young body: an aphorism describing the Chronic Fatigue Syndrome |
title_full_unstemmed | Old muscle in young body: an aphorism describing the Chronic Fatigue Syndrome |
title_short | Old muscle in young body: an aphorism describing the Chronic Fatigue Syndrome |
title_sort | old muscle in young body: an aphorism describing the chronic fatigue syndrome |
topic | Chronic Fatigue Syndrome / Myalgic Encephalomyelitis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176399/ https://www.ncbi.nlm.nih.gov/pubmed/30344981 http://dx.doi.org/10.4081/ejtm.2018.7688 |
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