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CRISPR-mediated deletion of prostate cancer risk-associated CTCF loop anchors identifies repressive chromatin loops

BACKGROUND: Recent genome-wide association studies (GWAS) have identified more than 100 loci associated with increased risk of prostate cancer, most of which are in non-coding regions of the genome. Understanding the function of these non-coding risk loci is critical to elucidate the genetic suscept...

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Detalles Bibliográficos
Autores principales:	Guo, Yu, Perez, Andrew A., Hazelett, Dennis J., Coetzee, Gerhard A., Rhie, Suhn Kyong, Farnham, Peggy J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176514/ https://www.ncbi.nlm.nih.gov/pubmed/30296942 http://dx.doi.org/10.1186/s13059-018-1531-0

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