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CRISPhieRmix: a hierarchical mixture model for CRISPR pooled screens

Pooled CRISPR screens allow researchers to interrogate genetic causes of complex phenotypes at the genome-wide scale and promise higher specificity and sensitivity compared to competing technologies. Unfortunately, two problems exist, particularly for CRISPRi/a screens: variability in guide efficien...

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Detalles Bibliográficos
Autores principales:	Daley, Timothy P., Lin, Zhixiang, Lin, Xueqiu, Liu, Yanxia, Wong, Wing Hung, Qi, Lei S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Method
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176515/ https://www.ncbi.nlm.nih.gov/pubmed/30296940 http://dx.doi.org/10.1186/s13059-018-1538-6

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