Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy

Alzheimer’s disease (AD), the most common form of dementia, is characterized by the abnormal accumulation of amyloid plaques and hyperphosphorylated tau aggregates, as well as microgliosis. Hemizygous missense variants in Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) are associated with e...

Descripción completa

Detalles Bibliográficos
Autores principales: Sayed, Faten A., Telpoukhovskaia, Maria, Kodama, Lay, Li, Yaqiao, Zhou, Yungui, Le, David, Hauduc, Axel, Ludwig, Connor, Gao, Fuying, Clelland, Claire, Zhan, Lihong, Cooper, Yonatan A., Davalos, Dimitrios, Akassoglou, Katerina, Coppola, Giovanni, Gan, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176614/
https://www.ncbi.nlm.nih.gov/pubmed/30232263
http://dx.doi.org/10.1073/pnas.1811411115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176614/
https://www.ncbi.nlm.nih.gov/pubmed/30232263
http://dx.doi.org/10.1073/pnas.1811411115

Ejemplares similares