Control of CCND1 ubiquitylation by the catalytic SAGA subunit USP22 is essential for cell cycle progression through G1 in cancer cells

Overexpression of the deubiquitylase ubiquitin-specific peptidase 22 (USP22) is a marker of aggressive cancer phenotypes like metastasis, therapy resistance, and poor survival. Functionally, this overexpression of USP22 actively contributes to tumorigenesis, as USP22 depletion blocks cancer cell cyc...

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Detalles Bibliográficos
Autores principales: Gennaro, Victoria J., Stanek, Timothy J., Peck, Amy R., Sun, Yunguang, Wang, Feng, Qie, Shuo, Knudsen, Karen E., Rui, Hallgeir, Butt, Tauseef, Diehl, J. Alan, McMahon, Steven B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176615/
https://www.ncbi.nlm.nih.gov/pubmed/30224477
http://dx.doi.org/10.1073/pnas.1807704115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176615/
https://www.ncbi.nlm.nih.gov/pubmed/30224477
http://dx.doi.org/10.1073/pnas.1807704115

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