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Snapshots of a modified nucleotide moving through the confines of a DNA polymerase

DNA polymerases have evolved to process the four canonical nucleotides accurately. Nevertheless, these enzymes are also known to process modified nucleotides, which is the key to numerous core biotechnology applications. Processing of modified nucleotides includes incorporation of the modified nucle...

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Detalles Bibliográficos
Autores principales: Kropp, Heike Maria, Dürr, Simon Leonard, Peter, Christine, Diederichs, Kay, Marx, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176618/
https://www.ncbi.nlm.nih.gov/pubmed/30224478
http://dx.doi.org/10.1073/pnas.1811518115