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Behavior of homing endonuclease gene drives targeting genes required for viability or female fertility with multiplexed guide RNAs
A gene drive method of particular interest for population suppression utilizes homing endonuclease genes (HEGs), wherein a site-specific, nuclease-encoding cassette is copied, in the germline, into a target gene whose loss of function results in loss of viability or fertility in homozygous, but not...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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National Academy of Sciences
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176634/ https://www.ncbi.nlm.nih.gov/pubmed/30224454 http://dx.doi.org/10.1073/pnas.1805278115 |