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3T proton MR Spectroscopy evaluation of spinal cord lesions

OBJECTIVE: The objective of this study was to evaluate intramedullary spinal cord lesions using magnetic resonance spectroscopy and correlate the results with histo-pathological examination (HPE). MATERIALS AND METHODS: Approval for this study was obtained from our institute ethical committee. Overa...

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Autores principales: Sathyanathan, Babu Peter, Raju, Bharathi Priya, Natarajan, Kailasanathan, Ranganathan, Ravi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176681/
https://www.ncbi.nlm.nih.gov/pubmed/30319204
http://dx.doi.org/10.4103/ijri.IJRI_122_17
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author Sathyanathan, Babu Peter
Raju, Bharathi Priya
Natarajan, Kailasanathan
Ranganathan, Ravi
author_facet Sathyanathan, Babu Peter
Raju, Bharathi Priya
Natarajan, Kailasanathan
Ranganathan, Ravi
author_sort Sathyanathan, Babu Peter
collection PubMed
description OBJECTIVE: The objective of this study was to evaluate intramedullary spinal cord lesions using magnetic resonance spectroscopy and correlate the results with histo-pathological examination (HPE). MATERIALS AND METHODS: Approval for this study was obtained from our institute ethical committee. Overall, 50 patients were recruited (29 male and 21 female), with a maximum age of 53 years and minimum age of 7 years. The mean age group of the study was 33 years. Standard magnetic resonance imaging (MRI) spine was done on a Siemens Skyra 3Tesla MRI scanner. MR Spectroscopy (MRS) was performed for all patients with intramedullary spinal lesions after getting written consent. It was performed using single-voxel method. The change in the metabolite peak was observed in each case and the results were compared with HPE. These collected data were analyzed using SPSS 16.0 version. Descriptive statistics, frequency analysis, and percentage analysis were used for categorical variables; and for continuous variables, mean and standard deviation were analyzed. McNemar's test was used to find the significance between conventional MRI MRS. In the above statistical tool, the probability value 0.05 is considered as significant level. RESULTS: From our study, we observed that by applying routine MRI sequences alone, we could only detect around 58% of the cases correctly. However, when MRS was done along with the conventional MR imaging, the number of cases detected significantly increased to 84%. By applying McNemar's test and comparing the conventional MRI and MRS with HPE, it was found that statistically significant difference exists with P value of 0.007. CONCLUSION: MRS of the spinal cord is a promising tool for research and diagnosis because it can provide additional information complementary to other non-invasive imaging methods. It is an emerging tool and adds new biomarker information for characterization of spinal cord tumors, to differentiate benign from malignant lesions and to prevent unnecessary biopsies and surgeries.
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spelling pubmed-61766812018-10-12 3T proton MR Spectroscopy evaluation of spinal cord lesions Sathyanathan, Babu Peter Raju, Bharathi Priya Natarajan, Kailasanathan Ranganathan, Ravi Indian J Radiol Imaging Neuroradiology & Head and Neck Imaging OBJECTIVE: The objective of this study was to evaluate intramedullary spinal cord lesions using magnetic resonance spectroscopy and correlate the results with histo-pathological examination (HPE). MATERIALS AND METHODS: Approval for this study was obtained from our institute ethical committee. Overall, 50 patients were recruited (29 male and 21 female), with a maximum age of 53 years and minimum age of 7 years. The mean age group of the study was 33 years. Standard magnetic resonance imaging (MRI) spine was done on a Siemens Skyra 3Tesla MRI scanner. MR Spectroscopy (MRS) was performed for all patients with intramedullary spinal lesions after getting written consent. It was performed using single-voxel method. The change in the metabolite peak was observed in each case and the results were compared with HPE. These collected data were analyzed using SPSS 16.0 version. Descriptive statistics, frequency analysis, and percentage analysis were used for categorical variables; and for continuous variables, mean and standard deviation were analyzed. McNemar's test was used to find the significance between conventional MRI MRS. In the above statistical tool, the probability value 0.05 is considered as significant level. RESULTS: From our study, we observed that by applying routine MRI sequences alone, we could only detect around 58% of the cases correctly. However, when MRS was done along with the conventional MR imaging, the number of cases detected significantly increased to 84%. By applying McNemar's test and comparing the conventional MRI and MRS with HPE, it was found that statistically significant difference exists with P value of 0.007. CONCLUSION: MRS of the spinal cord is a promising tool for research and diagnosis because it can provide additional information complementary to other non-invasive imaging methods. It is an emerging tool and adds new biomarker information for characterization of spinal cord tumors, to differentiate benign from malignant lesions and to prevent unnecessary biopsies and surgeries. Medknow Publications & Media Pvt Ltd 2018 /pmc/articles/PMC6176681/ /pubmed/30319204 http://dx.doi.org/10.4103/ijri.IJRI_122_17 Text en Copyright: © 2018 Indian Journal of Radiology and Imaging http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Neuroradiology & Head and Neck Imaging
Sathyanathan, Babu Peter
Raju, Bharathi Priya
Natarajan, Kailasanathan
Ranganathan, Ravi
3T proton MR Spectroscopy evaluation of spinal cord lesions
title 3T proton MR Spectroscopy evaluation of spinal cord lesions
title_full 3T proton MR Spectroscopy evaluation of spinal cord lesions
title_fullStr 3T proton MR Spectroscopy evaluation of spinal cord lesions
title_full_unstemmed 3T proton MR Spectroscopy evaluation of spinal cord lesions
title_short 3T proton MR Spectroscopy evaluation of spinal cord lesions
title_sort 3t proton mr spectroscopy evaluation of spinal cord lesions
topic Neuroradiology & Head and Neck Imaging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176681/
https://www.ncbi.nlm.nih.gov/pubmed/30319204
http://dx.doi.org/10.4103/ijri.IJRI_122_17
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