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Arousal increases neural gain via the locus coeruleus-norepinephrine system in younger adults but not in older adults
In younger adults, arousal amplifies attentional focus to the most salient or goal-relevant information while suppressing other information. A computational model of how the locus coeruleus-norepinephrine (LC-NE) system can implement this increased selectivity under arousal and an fMRI study compari...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176734/ https://www.ncbi.nlm.nih.gov/pubmed/30320223 http://dx.doi.org/10.1038/s41562-018-0344-1 |
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author | Lee, Tae-Ho Greening, Steven G. Ueno, Taiji Clewett, David Ponzio, Allison Sakaki, Michiko Mather, Mara |
author_facet | Lee, Tae-Ho Greening, Steven G. Ueno, Taiji Clewett, David Ponzio, Allison Sakaki, Michiko Mather, Mara |
author_sort | Lee, Tae-Ho |
collection | PubMed |
description | In younger adults, arousal amplifies attentional focus to the most salient or goal-relevant information while suppressing other information. A computational model of how the locus coeruleus-norepinephrine (LC-NE) system can implement this increased selectivity under arousal and an fMRI study comparing how arousal affects younger and older adults’ processing indicate that the amplification of salient stimuli and the suppression of non-salient stimuli are separate processes, with aging affecting suppression without impacting amplification under arousal. In the fMRI study, arousal increased processing of salient stimuli and decreased processing of non-salient stimuli for younger adults. In contrast, for older adults, arousal increased processing of both low and high salience stimuli, generally increasing excitatory responses to visual stimuli. Older adults also showed decline in LC functional connectivity with frontoparietal networks that coordinate attentional selectivity. Thus, among older adults, arousal increases the potential for distraction from non-salient stimuli. |
format | Online Article Text |
id | pubmed-6176734 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
record_format | MEDLINE/PubMed |
spelling | pubmed-61767342018-11-07 Arousal increases neural gain via the locus coeruleus-norepinephrine system in younger adults but not in older adults Lee, Tae-Ho Greening, Steven G. Ueno, Taiji Clewett, David Ponzio, Allison Sakaki, Michiko Mather, Mara Nat Hum Behav Article In younger adults, arousal amplifies attentional focus to the most salient or goal-relevant information while suppressing other information. A computational model of how the locus coeruleus-norepinephrine (LC-NE) system can implement this increased selectivity under arousal and an fMRI study comparing how arousal affects younger and older adults’ processing indicate that the amplification of salient stimuli and the suppression of non-salient stimuli are separate processes, with aging affecting suppression without impacting amplification under arousal. In the fMRI study, arousal increased processing of salient stimuli and decreased processing of non-salient stimuli for younger adults. In contrast, for older adults, arousal increased processing of both low and high salience stimuli, generally increasing excitatory responses to visual stimuli. Older adults also showed decline in LC functional connectivity with frontoparietal networks that coordinate attentional selectivity. Thus, among older adults, arousal increases the potential for distraction from non-salient stimuli. 2018-05-07 2018 /pmc/articles/PMC6176734/ /pubmed/30320223 http://dx.doi.org/10.1038/s41562-018-0344-1 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Lee, Tae-Ho Greening, Steven G. Ueno, Taiji Clewett, David Ponzio, Allison Sakaki, Michiko Mather, Mara Arousal increases neural gain via the locus coeruleus-norepinephrine system in younger adults but not in older adults |
title | Arousal increases neural gain via the locus coeruleus-norepinephrine system in younger adults but not in older adults |
title_full | Arousal increases neural gain via the locus coeruleus-norepinephrine system in younger adults but not in older adults |
title_fullStr | Arousal increases neural gain via the locus coeruleus-norepinephrine system in younger adults but not in older adults |
title_full_unstemmed | Arousal increases neural gain via the locus coeruleus-norepinephrine system in younger adults but not in older adults |
title_short | Arousal increases neural gain via the locus coeruleus-norepinephrine system in younger adults but not in older adults |
title_sort | arousal increases neural gain via the locus coeruleus-norepinephrine system in younger adults but not in older adults |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176734/ https://www.ncbi.nlm.nih.gov/pubmed/30320223 http://dx.doi.org/10.1038/s41562-018-0344-1 |
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