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Glucocorticoids cause mandibular bone fragility and suppress osteocyte perilacunar-canalicular remodeling

Osteocytes support dynamic, cell-intrinsic resorption and deposition of bone matrix through a process called perilacunar/canalicular remodeling (PLR). In long bones, PLR depends on MMP13 and is tightly regulated by PTH, sclerostin, TGFβ, and glucocorticoids. However, PLR is regulated differently in...

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Detalles Bibliográficos
Autores principales:	Alemi, A. Sean, Mazur, Courtney M., Fowler, Tristan W., Woo, Jonathon J., Knott, P. Daniel, Alliston, Tamara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176786/ https://www.ncbi.nlm.nih.gov/pubmed/30306100 http://dx.doi.org/10.1016/j.bonr.2018.09.004

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