Gene Signature–Based Approach Identified MEK1/2 as a Potential Target Associated With Relapse After Anti-TNFα Treatment for Crohn’s Disease

BACKGROUND: Anti–tumor necrosis factor alpha (anti-TNFα) therapy has become the mainstay of therapy for Crohn’s disease (CD). However, post-therapy, the recurrence rate is still high. The aim of this study was to dissect the molecular mechanism for recurrence of CD treated with anti-TNFα therapy and...

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Detalles Bibliográficos
Autores principales: Gamo, Kanae, Okuzono, Yuumi, Yabuki, Masato, Ochi, Takashi, Sugimura, Kyoko, Sato, Yosuke, Sagara, Masaki, Hayashi, Hiroki, Ishimura, Yoshimasa, Nishimoto, Yutaka, Murakawa, Yusuke, Shiokawa, Zenyu, Gotoh, Masayuki, Miyazaki, Takahiro, Ebisuno, Yukihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Original Basic Science Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176896/
https://www.ncbi.nlm.nih.gov/pubmed/29669006
http://dx.doi.org/10.1093/ibd/izy079

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