LIF-dependent survival of embryonic stem cells is regulated by a novel palmitoylated Gab1 signalling protein

The cytokine leukaemia inhibitory factor (LIF) promotes self-renewal of mouse embryonic stem cells (ESCs) through activation of the transcription factor Stat3. However, the contribution of other ancillary pathways stimulated by LIF in ESCs, such as the MAPK and PI3K pathways, is less well understood...

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Detalles Bibliográficos
Autores principales: Sutherland, Linda, Ruhe, Madeleine, Gattegno-Ho, Daniela, Mann, Karanjit, Greaves, Jennifer, Koscielniak, Magdalena, Meek, Stephen, Lu, Zen, Waterfall, Martin, Taylor, Ryan, Tsakiridis, Anestis, Brown, Helen, Maciver, Sutherland K., Joshi, Anagha, Clinton, Michael, Chamberlain, Luke H., Smith, Austin, Burdon, Tom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176924/
https://www.ncbi.nlm.nih.gov/pubmed/30154213
http://dx.doi.org/10.1242/jcs.222257

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