The class I myosin MYO1D binds to lipid and protects against colitis

Myosin ID (MYO1D) is a member of the class I myosin family. We screened 48,649 third generation (G3) germline mutant mice derived from N-ethyl-N-nitrosourea-mutagenized grandsires for intestinal homeostasis abnormalities after oral administration of dextran sodium sulfate (DSS). We found and validat...

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Autores principales: McAlpine, William, Wang, Kuan-wen, Choi, Jin Huk, San Miguel, Miguel, McAlpine, Sarah Grace, Russell, Jamie, Ludwig, Sara, Li, Xiaohong, Tang, Miao, Zhan, Xiaoming, Choi, Mihwa, Wang, Tao, Bu, Chun Hui, Murray, Anne R., Moresco, Eva Marie Y., Turer, Emre E., Beutler, Bruce
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176994/
https://www.ncbi.nlm.nih.gov/pubmed/30279225
http://dx.doi.org/10.1242/dmm.035923
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author McAlpine, William
Wang, Kuan-wen
Choi, Jin Huk
San Miguel, Miguel
McAlpine, Sarah Grace
Russell, Jamie
Ludwig, Sara
Li, Xiaohong
Tang, Miao
Zhan, Xiaoming
Choi, Mihwa
Wang, Tao
Bu, Chun Hui
Murray, Anne R.
Moresco, Eva Marie Y.
Turer, Emre E.
Beutler, Bruce
author_facet McAlpine, William
Wang, Kuan-wen
Choi, Jin Huk
San Miguel, Miguel
McAlpine, Sarah Grace
Russell, Jamie
Ludwig, Sara
Li, Xiaohong
Tang, Miao
Zhan, Xiaoming
Choi, Mihwa
Wang, Tao
Bu, Chun Hui
Murray, Anne R.
Moresco, Eva Marie Y.
Turer, Emre E.
Beutler, Bruce
author_sort McAlpine, William
collection PubMed
description Myosin ID (MYO1D) is a member of the class I myosin family. We screened 48,649 third generation (G3) germline mutant mice derived from N-ethyl-N-nitrosourea-mutagenized grandsires for intestinal homeostasis abnormalities after oral administration of dextran sodium sulfate (DSS). We found and validated mutations in Myo1d as a cause of increased susceptibility to DSS-induced colitis. MYO1D is produced in the intestinal epithelium, and the colitis phenotype is dependent on the nonhematopoietic compartment of the mouse. Moreover, MYO1D appears to couple cytoskeletal elements to lipid in an ATP-dependent manner. These findings demonstrate that MYO1D is needed to maintain epithelial integrity and protect against DSS-induced colitis.
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spelling pubmed-61769942018-10-16 The class I myosin MYO1D binds to lipid and protects against colitis McAlpine, William Wang, Kuan-wen Choi, Jin Huk San Miguel, Miguel McAlpine, Sarah Grace Russell, Jamie Ludwig, Sara Li, Xiaohong Tang, Miao Zhan, Xiaoming Choi, Mihwa Wang, Tao Bu, Chun Hui Murray, Anne R. Moresco, Eva Marie Y. Turer, Emre E. Beutler, Bruce Dis Model Mech Research Article Myosin ID (MYO1D) is a member of the class I myosin family. We screened 48,649 third generation (G3) germline mutant mice derived from N-ethyl-N-nitrosourea-mutagenized grandsires for intestinal homeostasis abnormalities after oral administration of dextran sodium sulfate (DSS). We found and validated mutations in Myo1d as a cause of increased susceptibility to DSS-induced colitis. MYO1D is produced in the intestinal epithelium, and the colitis phenotype is dependent on the nonhematopoietic compartment of the mouse. Moreover, MYO1D appears to couple cytoskeletal elements to lipid in an ATP-dependent manner. These findings demonstrate that MYO1D is needed to maintain epithelial integrity and protect against DSS-induced colitis. The Company of Biologists Ltd 2018-09-01 2018-09-27 /pmc/articles/PMC6176994/ /pubmed/30279225 http://dx.doi.org/10.1242/dmm.035923 Text en © 2018. Published by The Company of Biologists Ltd http://creativecommons.org/licenses/by/3.0This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Research Article
McAlpine, William
Wang, Kuan-wen
Choi, Jin Huk
San Miguel, Miguel
McAlpine, Sarah Grace
Russell, Jamie
Ludwig, Sara
Li, Xiaohong
Tang, Miao
Zhan, Xiaoming
Choi, Mihwa
Wang, Tao
Bu, Chun Hui
Murray, Anne R.
Moresco, Eva Marie Y.
Turer, Emre E.
Beutler, Bruce
The class I myosin MYO1D binds to lipid and protects against colitis
title The class I myosin MYO1D binds to lipid and protects against colitis
title_full The class I myosin MYO1D binds to lipid and protects against colitis
title_fullStr The class I myosin MYO1D binds to lipid and protects against colitis
title_full_unstemmed The class I myosin MYO1D binds to lipid and protects against colitis
title_short The class I myosin MYO1D binds to lipid and protects against colitis
title_sort class i myosin myo1d binds to lipid and protects against colitis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176994/
https://www.ncbi.nlm.nih.gov/pubmed/30279225
http://dx.doi.org/10.1242/dmm.035923
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