Zoledronic acid prevents pagetic-like lesions and accelerated bone loss in the p62(P394L) mouse model of Paget's disease

Paget's disease of bone (PDB) is an age-related metabolic bone disorder, characterised by focally increased and disorganised bone remodelling initiated by abnormal and hyperactive osteoclasts. The germline P392L mutation of SQSTM1 (encoding p62) is a strong genetic risk factor for PDB in humans...

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Detalles Bibliográficos
Autores principales: Daroszewska, Anna, Rose, Lorraine, Sarsam, Nadine, Charlesworth, Gemma, Prior, Amanda, Rose, Kenneth, Ralston, Stuart H., van ‘t Hof, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177010/
https://www.ncbi.nlm.nih.gov/pubmed/30154079
http://dx.doi.org/10.1242/dmm.035576

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