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Bi-atrial cardiac myxoma with glandular differentiation: a case report with detailed radiologic-pathologic correlation

INTRODUCTION: Myxoma is the most common cardiac benign tumour. While a typical myxoma is generally a straightforward diagnosis, some myxomas have unusual features that can make the diagnosis challenging. Glandular myxomas and metastatic adenocarcinomas, the most common type of metastatic carcinoma t...

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Autores principales: Flint, Nir, Siegel, Robert J, Bannykh, Serguei, Luthringer, Daniel J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177082/
https://www.ncbi.nlm.nih.gov/pubmed/31020125
http://dx.doi.org/10.1093/ehjcr/yty045
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author Flint, Nir
Siegel, Robert J
Bannykh, Serguei
Luthringer, Daniel J
author_facet Flint, Nir
Siegel, Robert J
Bannykh, Serguei
Luthringer, Daniel J
author_sort Flint, Nir
collection PubMed
description INTRODUCTION: Myxoma is the most common cardiac benign tumour. While a typical myxoma is generally a straightforward diagnosis, some myxomas have unusual features that can make the diagnosis challenging. Glandular myxomas and metastatic adenocarcinomas, the most common type of metastatic carcinoma to the heart, can have very similar features. CASE PRESENTATION: We report a 60-year old man who presented with progressive shortness of breath on exertion. Echocardiography demonstrated a large heterogeneous, cystic left and right atrial mass. He was referred for surgery where a smooth and multilobulated left atrial mass was excised. Histopathological analysis with special stains revealed an unusual form of cardiac myxoma with extensive glandular differentiation. DISCUSSION: Cardiac myxomas can present with diverse clinical, radiological, and pathological features. Echocardiography is a modality of choice for diagnosis but can also miss small or multiple masses. Cardiac myxoma with glandular features is a rare type of myxoma. In our case, there was extensive glandular differentiation and the echocardiographic appearance provided clues for the unusual features of the tumour, suggesting a potential role for echocardiography in the detection and recognition of this morphologic histologic variation.
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spelling pubmed-61770822019-04-24 Bi-atrial cardiac myxoma with glandular differentiation: a case report with detailed radiologic-pathologic correlation Flint, Nir Siegel, Robert J Bannykh, Serguei Luthringer, Daniel J Eur Heart J Case Rep Case Reports INTRODUCTION: Myxoma is the most common cardiac benign tumour. While a typical myxoma is generally a straightforward diagnosis, some myxomas have unusual features that can make the diagnosis challenging. Glandular myxomas and metastatic adenocarcinomas, the most common type of metastatic carcinoma to the heart, can have very similar features. CASE PRESENTATION: We report a 60-year old man who presented with progressive shortness of breath on exertion. Echocardiography demonstrated a large heterogeneous, cystic left and right atrial mass. He was referred for surgery where a smooth and multilobulated left atrial mass was excised. Histopathological analysis with special stains revealed an unusual form of cardiac myxoma with extensive glandular differentiation. DISCUSSION: Cardiac myxomas can present with diverse clinical, radiological, and pathological features. Echocardiography is a modality of choice for diagnosis but can also miss small or multiple masses. Cardiac myxoma with glandular features is a rare type of myxoma. In our case, there was extensive glandular differentiation and the echocardiographic appearance provided clues for the unusual features of the tumour, suggesting a potential role for echocardiography in the detection and recognition of this morphologic histologic variation. Oxford University Press 2018-04-16 /pmc/articles/PMC6177082/ /pubmed/31020125 http://dx.doi.org/10.1093/ehjcr/yty045 Text en © The Author(s) 2018. Published by Oxford University Press on behalf of the European Society of Cardiology. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Case Reports
Flint, Nir
Siegel, Robert J
Bannykh, Serguei
Luthringer, Daniel J
Bi-atrial cardiac myxoma with glandular differentiation: a case report with detailed radiologic-pathologic correlation
title Bi-atrial cardiac myxoma with glandular differentiation: a case report with detailed radiologic-pathologic correlation
title_full Bi-atrial cardiac myxoma with glandular differentiation: a case report with detailed radiologic-pathologic correlation
title_fullStr Bi-atrial cardiac myxoma with glandular differentiation: a case report with detailed radiologic-pathologic correlation
title_full_unstemmed Bi-atrial cardiac myxoma with glandular differentiation: a case report with detailed radiologic-pathologic correlation
title_short Bi-atrial cardiac myxoma with glandular differentiation: a case report with detailed radiologic-pathologic correlation
title_sort bi-atrial cardiac myxoma with glandular differentiation: a case report with detailed radiologic-pathologic correlation
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177082/
https://www.ncbi.nlm.nih.gov/pubmed/31020125
http://dx.doi.org/10.1093/ehjcr/yty045
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