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Tankyrases maintain homeostasis of intestinal epithelium by preventing cell death

Lgr5(+) intestinal stem cells are crucial for fast homeostatic renewal of intestinal epithelium and Wnt/β-catenin signaling plays an essential role in this process by sustaining stem cell self-renewal. The poly(ADP-ribose) polymerases tankyrases (TNKSs) mediate protein poly-ADP-ribosylation and are...

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Detalles Bibliográficos
Autores principales:	Ye, Pan, Chiang, Y. Jeffrey, Qi, Zhen, Li, Yehua, Wang, Shan, Liu, Yuan, Li, Xintong, Chen, Ye-Guang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177203/ https://www.ncbi.nlm.nih.gov/pubmed/30260955 http://dx.doi.org/10.1371/journal.pgen.1007697

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