Alpha-fetoprotein inhibits autophagy to promote malignant behaviour in hepatocellular carcinoma cells by activating PI3K/AKT/mTOR signalling

Alpha-fetoprotein (AFP) has been recognized as a key regulator of cell proliferation in hepatocellular carcinoma (HCC). However, whether AFP functions in cancer cell autophagy remains unknown. This study investigated the effects of AFP on autophagy in HCC cells. The role of AFP was studied in two HC...

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Detalles Bibliográficos
Autores principales: Wang, Shanshan, Zhu, Mingyue, Wang, Qiaoyun, Hou, Yuli, Li, Lei, Weng, Honglei, Zhao, Yan, Chen, Dexi, Ding, Huiguo, Guo, Junli, Li, Mengsen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177398/
https://www.ncbi.nlm.nih.gov/pubmed/30301886
http://dx.doi.org/10.1038/s41419-018-1036-5

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