Cargando…

Morphological changes, nitric oxide production, and phagocytosis are triggered in vitro in microglia by bloodstream forms of Trypanosoma brucei

The flagellated parasite Trypanosoma brucei is the causative agent of Human African Trypanosomiasis (HAT). By a mechanism not well understood yet, trypanosomes enter the central nervous system (CNS), invade the brain parenchyma, and cause a fatal encephalopathy if is not treated. Trypanosomes are fa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Figarella, Katherine, Uzcategui, Nestor L., Mogk, Stefan, Wild, Katleen, Fallier-Becker, Petra, Neher, Jonas J., Duszenko, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177420/ https://www.ncbi.nlm.nih.gov/pubmed/30302029 http://dx.doi.org/10.1038/s41598-018-33395-x

Ejemplares similares

Transmigration of Trypanosoma brucei across an in vitro blood-cerebrospinal fluid barrier
por: Speidel, Annika, et al.
Publicado: (2022)

Live imaging of microglia during sleeping sickness reveals early and heterogeneous inflammatory responses
por: Uzcategui, Nestor L., et al.
Publicado: (2023)

Cerebral inducible nitric oxide synthase protein expression in microglia, astrocytes and neurons in Trypanosoma brucei brucei-infected rats
por: Cespuglio, Raymond, et al.
Publicado: (2019)

Neuropathogenesis caused by Trypanosoma brucei, still an enigma to be unveiled
por: Figarella, Katherine
Publicado: (2021)

Centromere-associated topoisomerase activity in bloodstream form Trypanosoma brucei
por: Obado, Samson O., et al.
Publicado: (2011)

Pyrimidine Biosynthesis Is Not an Essential Function for Trypanosoma brucei Bloodstream Forms
por: Ali, Juma A. M., et al.
Publicado: (2013)

Bloodstream form pre-adaptation to the tsetse fly in Trypanosoma brucei
por: Rico, Eva, et al.
Publicado: (2013)

In vitro growth inhibition of bloodstream forms of Trypanosoma brucei and Trypanosoma congolense by iron chelators
por: Merschjohann, Karin, et al.
Publicado: (2006)

Primary Phagocytosis of Neurons by Inflamed Microglia: Potential Roles in Neurodegeneration
por: Neher, Jonas J., et al.
Publicado: (2012)

Isolation and characterization of kinetoplast DNA from bloodstream form of Trypanosoma brucei
por: Fairlamb, A. H., et al.
Publicado: (1978)

KREX2 Is Not Essential for Either Procyclic or Bloodstream Form Trypanosoma brucei
por: Carnes, Jason, et al.
Publicado: (2012)

The ethanolamine branch of the Kennedy pathway is essential in the bloodstream form of Trypanosoma brucei
por: Gibellini, Federica, et al.
Publicado: (2009)

Cell density-dependent ectopic expression in bloodstream form Trypanosoma brucei
por: Ali, Moazzam, et al.
Publicado: (2013)

Mitochondrial growth during the cell cycle of Trypanosoma brucei bloodstream forms
por: Jakob, Martin, et al.
Publicado: (2016)

Gluconeogenesis using glycerol as a substrate in bloodstream-form Trypanosoma brucei
por: Kovářová, Julie, et al.
Publicado: (2018)

Analysis of the Trypanosoma brucei EATRO 164 Bloodstream Guide RNA Transcriptome
por: Kirby, Laura E., et al.
Publicado: (2016)

Novel aspects of iron homeostasis in pathogenic bloodstream form Trypanosoma brucei
por: Gilabert Carbajo, Carla, et al.
Publicado: (2021)

In vitro culture of freshly isolated Trypanosoma brucei brucei bloodstream forms results in gene copy-number changes
por: Mulindwa, Julius, et al.
Publicado: (2021)

Casein kinase 1 isoform 2 is essential for bloodstream form Trypanosoma brucei()
por: Urbaniak, Michael D.
Publicado: (2009)

The Phosphoproteome of Bloodstream Form Trypanosoma brucei, Causative Agent of African Sleeping Sickness
por: Nett, Isabelle R. E., et al.
Publicado: (2009)

Channel-Forming Activities in the Glycosomal Fraction from the Bloodstream Form of Trypanosoma brucei
por: Gualdron-López, Melisa, et al.
Publicado: (2012)

Comparative SILAC Proteomic Analysis of Trypanosoma brucei Bloodstream and Procyclic Lifecycle Stages
por: Urbaniak, Michael D., et al.
Publicado: (2012)

Cytokinesis in Bloodstream Stage Trypanosoma brucei Requires a Family of Katanins and Spastin
por: Benz, Corinna, et al.
Publicado: (2012)

The essential roles of cytidine diphosphate‐diacylglycerol synthase in bloodstream form Trypanosoma brucei
por: Lilley, Alison C., et al.
Publicado: (2014)

NADH dehydrogenase of Trypanosoma brucei is important for efficient acetate production in bloodstream forms
por: Surve, Sachin V., et al.
Publicado: (2017)

A paradigm shift: The mitoproteomes of procyclic and bloodstream Trypanosoma brucei are comparably complex
por: Zíková, Alena, et al.
Publicado: (2017)

Vacuolar ATPase depletion contributes to dysregulation of endocytosis in bloodstream forms of Trypanosoma brucei
por: Xu, Zhi-Shen, et al.
Publicado: (2020)

Proteome turnover in the bloodstream and procyclic forms of Trypanosoma brucei measured by quantitative proteomics
por: Tinti, Michele, et al.
Publicado: (2019)

Nucleotide sugar biosynthesis occurs in the glycosomes of procyclic and bloodstream form Trypanosoma brucei
por: Sampaio Guther, Maria Lucia, et al.
Publicado: (2021)

FAZ assembly in bloodstream form Trypanosoma brucei requires kinesin KIN-E
por: Albisetti, Anna C., et al.
Publicado: (2023)

Neuronal Death Induced by Nanomolar Amyloid β Is Mediated by Primary Phagocytosis of Neurons by Microglia
por: Neniskyte, Urte, et al.
Publicado: (2011)

Cysteine eliminates the feeder cell requirement for cultivation of Trypanosoma brucei bloodstream forms in vitro
Publicado: (1985)

Correction: Cytokinesis in Bloodstream Stage Trypanosoma brucei Requires a Family of Katanins and Spastin
por: Benz, Corinna, et al.
Publicado: (2012)

The Cytological Events and Molecular Control of Life Cycle Development of Trypanosoma brucei in the Mammalian Bloodstream
por: Silvester, Eleanor, et al.
Publicado: (2017)

Alkaloids Induce Programmed Cell Death in Bloodstream Forms of Trypanosomes (Trypanosoma b. brucei)
por: Rosenkranz, Vera, et al.
Publicado: (2008)

Halogenated tryptophan derivatives disrupt essential transamination mechanisms in bloodstream form Trypanosoma brucei
por: Cockram, Peter E., et al.
Publicado: (2020)

Several different sequences are implicated in bloodstream-form-specific gene expression in Trypanosoma brucei
por: Bishola Tshitenge, Tania, et al.
Publicado: (2022)

Identification of a Novel Prostaglandin F(2α) Synthase in Trypanosoma brucei
por: Kubata, Bruno Kilunga, et al.
Publicado: (2000)

SUMOylation in Trypanosoma brucei
por: Klein, Cornelia Andrea, et al.
Publicado: (2013)

Nuclear DBF-2-related Kinases Are Essential Regulators of Cytokinesis in Bloodstream Stage Trypanosoma brucei
por: Ma, Jiangtao, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_vvi431f90jkdtph89trt4ik8pu