Peptide-oligonucleotide conjugates exhibiting pyrimidine-X cleavage specificity efficiently silence miRNA target acting synergistically with RNase H

Taking into account the important role of miRNA in carcinogenesis, oncogenic miRNAs are attractive molecules for gene-targeted therapy. Here, we developed a novel series of peptide-oligonucleotide conjugates exhibiting ribonuclease activity targeted to highly oncogenic miRNAs miR-21 and miR-17. When...

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Detalles Bibliográficos
Autores principales: Patutina, O. A., Bazhenov, M. A., Miroshnichenko, S. K., Mironova, N. L., Pyshnyi, D. V., Vlassov, V. V., Zenkova, M. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177439/
https://www.ncbi.nlm.nih.gov/pubmed/30302012
http://dx.doi.org/10.1038/s41598-018-33331-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177439/
https://www.ncbi.nlm.nih.gov/pubmed/30302012
http://dx.doi.org/10.1038/s41598-018-33331-z

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