Structural Rearrangements Maintain the Glycan Shield of an HIV-1 Envelope Trimer After the Loss of a Glycan

The HIV-1 envelope (Env) glycoprotein is the primary target of the humoral immune response and a critical vaccine candidate. However, Env is densely glycosylated and thereby substantially protected from neutralisation. Importantly, glycan N301 shields V3 loop and CD4 binding site epitopes from neutr...

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Detalles Bibliográficos
Autores principales: Ferreira, Roux-Cil, Grant, Oliver C., Moyo, Thandeka, Dorfman, Jeffrey R., Woods, Robert J., Travers, Simon A., Wood, Natasha T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177452/
https://www.ncbi.nlm.nih.gov/pubmed/30302011
http://dx.doi.org/10.1038/s41598-018-33390-2

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