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Circadian rhythms and psychiatric profiles in young adults with unipolar depressive disorders
Abnormalities in circadian rhythms have been reported in people with mood disorders, but these abnormalities are marked by considerable inter-individual variability. This study aimed to identify pathophysiological subgroups on the basis of circadian markers and evaluate how these subgroups relate to...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177460/ https://www.ncbi.nlm.nih.gov/pubmed/30301878 http://dx.doi.org/10.1038/s41398-018-0255-y |
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author | Robillard, Rébecca Carpenter, Joanne S. Rogers, Naomi L. Fares, Sarah Grierson, Ashlee B. Hermens, Daniel F. Naismith, Sharon L. Mullin, Sharon J. Feilds, Kristy-Lee Glozier, Nick Scott, Elizabeth M. Hickie, Ian B. |
author_facet | Robillard, Rébecca Carpenter, Joanne S. Rogers, Naomi L. Fares, Sarah Grierson, Ashlee B. Hermens, Daniel F. Naismith, Sharon L. Mullin, Sharon J. Feilds, Kristy-Lee Glozier, Nick Scott, Elizabeth M. Hickie, Ian B. |
author_sort | Robillard, Rébecca |
collection | PubMed |
description | Abnormalities in circadian rhythms have been reported in people with mood disorders, but these abnormalities are marked by considerable inter-individual variability. This study aimed to identify pathophysiological subgroups on the basis of circadian markers and evaluate how these subgroups relate to psychiatric profiles. Thirty-five young adults (18–31 years old) receiving clinical care for unipolar depressive disorders and 15 healthy controls took part to this study. The Hamilton Rating Scale for Depression and the Young Mania rating scale were used to evaluate the severity of mood symptoms in participants with depressive disorders. All participant underwent ambulatory sleep monitoring with actigraphy for about 12 days before attending a laboratory-based chronobiological assessment which included repeated salivary samples to determine dim light melatonin onset (DLMO) and continuous core body temperature (CBT) monitoring using an ingestible temperature sensor. Cluster analyses were conducted across all participants to identify subgroups with consistent circadian timing profiles based on DLMO and the nocturnal minima of CBT. Two clusters were identified: ‘delayed’ and ‘conventional timing’ circadian phase. Descriptive analyses showed that the delayed cluster was characterised by abnormal time relationships between circadian phase markers and the sleep–wake cycle. Importantly, individuals from the delayed cluster had worse depression severity (t(28) = −2.7, p = 0.011) and hypomanic symptoms (Z = −2.2, p = 0.041) than their peers with conventional circadian timing. These findings suggest that delayed and disorganised circadian rhythms may be linked to worse psychiatric profiles in young people with depressive disorders. |
format | Online Article Text |
id | pubmed-6177460 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-61774602018-10-11 Circadian rhythms and psychiatric profiles in young adults with unipolar depressive disorders Robillard, Rébecca Carpenter, Joanne S. Rogers, Naomi L. Fares, Sarah Grierson, Ashlee B. Hermens, Daniel F. Naismith, Sharon L. Mullin, Sharon J. Feilds, Kristy-Lee Glozier, Nick Scott, Elizabeth M. Hickie, Ian B. Transl Psychiatry Article Abnormalities in circadian rhythms have been reported in people with mood disorders, but these abnormalities are marked by considerable inter-individual variability. This study aimed to identify pathophysiological subgroups on the basis of circadian markers and evaluate how these subgroups relate to psychiatric profiles. Thirty-five young adults (18–31 years old) receiving clinical care for unipolar depressive disorders and 15 healthy controls took part to this study. The Hamilton Rating Scale for Depression and the Young Mania rating scale were used to evaluate the severity of mood symptoms in participants with depressive disorders. All participant underwent ambulatory sleep monitoring with actigraphy for about 12 days before attending a laboratory-based chronobiological assessment which included repeated salivary samples to determine dim light melatonin onset (DLMO) and continuous core body temperature (CBT) monitoring using an ingestible temperature sensor. Cluster analyses were conducted across all participants to identify subgroups with consistent circadian timing profiles based on DLMO and the nocturnal minima of CBT. Two clusters were identified: ‘delayed’ and ‘conventional timing’ circadian phase. Descriptive analyses showed that the delayed cluster was characterised by abnormal time relationships between circadian phase markers and the sleep–wake cycle. Importantly, individuals from the delayed cluster had worse depression severity (t(28) = −2.7, p = 0.011) and hypomanic symptoms (Z = −2.2, p = 0.041) than their peers with conventional circadian timing. These findings suggest that delayed and disorganised circadian rhythms may be linked to worse psychiatric profiles in young people with depressive disorders. Nature Publishing Group UK 2018-10-09 /pmc/articles/PMC6177460/ /pubmed/30301878 http://dx.doi.org/10.1038/s41398-018-0255-y Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Robillard, Rébecca Carpenter, Joanne S. Rogers, Naomi L. Fares, Sarah Grierson, Ashlee B. Hermens, Daniel F. Naismith, Sharon L. Mullin, Sharon J. Feilds, Kristy-Lee Glozier, Nick Scott, Elizabeth M. Hickie, Ian B. Circadian rhythms and psychiatric profiles in young adults with unipolar depressive disorders |
title | Circadian rhythms and psychiatric profiles in young adults with unipolar depressive disorders |
title_full | Circadian rhythms and psychiatric profiles in young adults with unipolar depressive disorders |
title_fullStr | Circadian rhythms and psychiatric profiles in young adults with unipolar depressive disorders |
title_full_unstemmed | Circadian rhythms and psychiatric profiles in young adults with unipolar depressive disorders |
title_short | Circadian rhythms and psychiatric profiles in young adults with unipolar depressive disorders |
title_sort | circadian rhythms and psychiatric profiles in young adults with unipolar depressive disorders |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177460/ https://www.ncbi.nlm.nih.gov/pubmed/30301878 http://dx.doi.org/10.1038/s41398-018-0255-y |
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