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All-optical forward-viewing photoacoustic probe for high-resolution 3D endoscopy

A miniature forward-viewing endoscopic probe that provides high-resolution 3D photoacoustic images is demonstrated. The probe is of outer diameter 3.2 mm and comprised of a transparent Fabry-Pérot (FP) polymer-film ultrasound sensor that is located at the distal end of a rigid optical fiber bundle....

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Autores principales: Ansari, Rehman, Zhang, Edward Z., Desjardins, Adrien E., Beard, Paul C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177463/
https://www.ncbi.nlm.nih.gov/pubmed/30323927
http://dx.doi.org/10.1038/s41377-018-0070-5
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author Ansari, Rehman
Zhang, Edward Z.
Desjardins, Adrien E.
Beard, Paul C.
author_facet Ansari, Rehman
Zhang, Edward Z.
Desjardins, Adrien E.
Beard, Paul C.
author_sort Ansari, Rehman
collection PubMed
description A miniature forward-viewing endoscopic probe that provides high-resolution 3D photoacoustic images is demonstrated. The probe is of outer diameter 3.2 mm and comprised of a transparent Fabry-Pérot (FP) polymer-film ultrasound sensor that is located at the distal end of a rigid optical fiber bundle. Excitation laser pulses are coupled simultaneously into all cores of the bundle and are transmitted through the FP sensor to provide wide-field tissue illumination at the distal end. The resulting photoacoustic waves are mapped in 2D by sequentially scanning the input end of the bundle with an interrogation laser beam in order to individually address different points on the FP sensor. In this way, the sensor acts as a high-density ultrasound array that is comprised of 50,000 individual elements, each of which is 12 µm in diameter, within the 3.2 mm diameter footprint of the probe. The fine spatial sampling that this affords, along with the wide bandwidth (f(-3dB = )34 MHz) of the sensor, enables a high-resolution photoacoustic image to be reconstructed. The measured on-axis lateral resolution of the probe was depth-dependent and ranged from 45-170 µm for depths between 1 and 7 mm, and the vertical resolution was 31 µm over the same depth range. The system was evaluated by acquiring 3D images of absorbing phantoms and the microvascular anatomies of a duck embryo and mouse skin. Excellent image fidelity was demonstrated. It is anticipated that this type of probe could find application as a tool for guiding laparoscopic procedures, fetal surgery and other minimally invasive interventions that require a millimeter-scale forward-viewing 3D photoacoustic imaging probe.
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spelling pubmed-61774632018-10-15 All-optical forward-viewing photoacoustic probe for high-resolution 3D endoscopy Ansari, Rehman Zhang, Edward Z. Desjardins, Adrien E. Beard, Paul C. Light Sci Appl Article A miniature forward-viewing endoscopic probe that provides high-resolution 3D photoacoustic images is demonstrated. The probe is of outer diameter 3.2 mm and comprised of a transparent Fabry-Pérot (FP) polymer-film ultrasound sensor that is located at the distal end of a rigid optical fiber bundle. Excitation laser pulses are coupled simultaneously into all cores of the bundle and are transmitted through the FP sensor to provide wide-field tissue illumination at the distal end. The resulting photoacoustic waves are mapped in 2D by sequentially scanning the input end of the bundle with an interrogation laser beam in order to individually address different points on the FP sensor. In this way, the sensor acts as a high-density ultrasound array that is comprised of 50,000 individual elements, each of which is 12 µm in diameter, within the 3.2 mm diameter footprint of the probe. The fine spatial sampling that this affords, along with the wide bandwidth (f(-3dB = )34 MHz) of the sensor, enables a high-resolution photoacoustic image to be reconstructed. The measured on-axis lateral resolution of the probe was depth-dependent and ranged from 45-170 µm for depths between 1 and 7 mm, and the vertical resolution was 31 µm over the same depth range. The system was evaluated by acquiring 3D images of absorbing phantoms and the microvascular anatomies of a duck embryo and mouse skin. Excellent image fidelity was demonstrated. It is anticipated that this type of probe could find application as a tool for guiding laparoscopic procedures, fetal surgery and other minimally invasive interventions that require a millimeter-scale forward-viewing 3D photoacoustic imaging probe. Nature Publishing Group UK 2018-10-10 /pmc/articles/PMC6177463/ /pubmed/30323927 http://dx.doi.org/10.1038/s41377-018-0070-5 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Ansari, Rehman
Zhang, Edward Z.
Desjardins, Adrien E.
Beard, Paul C.
All-optical forward-viewing photoacoustic probe for high-resolution 3D endoscopy
title All-optical forward-viewing photoacoustic probe for high-resolution 3D endoscopy
title_full All-optical forward-viewing photoacoustic probe for high-resolution 3D endoscopy
title_fullStr All-optical forward-viewing photoacoustic probe for high-resolution 3D endoscopy
title_full_unstemmed All-optical forward-viewing photoacoustic probe for high-resolution 3D endoscopy
title_short All-optical forward-viewing photoacoustic probe for high-resolution 3D endoscopy
title_sort all-optical forward-viewing photoacoustic probe for high-resolution 3d endoscopy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177463/
https://www.ncbi.nlm.nih.gov/pubmed/30323927
http://dx.doi.org/10.1038/s41377-018-0070-5
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