Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells

Despite their inherent proximity to circulating oxygen and nutrients, endothelial cells (ECs) oxidize only a minor fraction of glucose in mitochondria, a metabolic specialization that is poorly understood. Here we show that the glycolytic enzyme pyruvate kinase M2 (PKM2) limits glucose oxidation, an...

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Detalles Bibliográficos
Autores principales: Stone, Oliver A., El-Brolosy, Mohamed, Wilhelm, Kerstin, Liu, Xiaojing, Romão, Ana M., Grillo, Elisabetta, Lai, Jason K. H., Günther, Stefan, Jeratsch, Sylvia, Kuenne, Carsten, Lee, I-Ching, Braun, Thomas, Santoro, Massimo M., Locasale, Jason W., Potente, Michael, Stainier, Didier Y. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177464/
https://www.ncbi.nlm.nih.gov/pubmed/30301887
http://dx.doi.org/10.1038/s41467-018-06406-8

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