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The road less traveled: strategies to enhance the frequency of homology-directed repair (HDR) for increased efficiency of CRISPR/Cas-mediated transgenesis
Non-homologous end joining (NHEJ), and to a lesser extent, the error-free pathway known as homology-directed repair (HDR) are cellular mechanisms for recovery from double-strand DNA breaks (DSB) induced by RNA-guided programmable nuclease CRISPR/Cas. Since NHEJ is equivalent to using a duck tape to...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Korean Society for Biochemistry and Molecular Biology
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177507/ https://www.ncbi.nlm.nih.gov/pubmed/30103848 http://dx.doi.org/10.5483/BMBRep.2018.51.9.187 |