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GAPLINC is a predictor of poor prognosis and regulates cell migration and invasion in osteosarcoma

Gastric adenocarcinoma predictive long intergenic non-coding (GAPLINC) is a novel long non-coding RNA (lncRNA) and has been found to function as an oncogenic lncRNA in gastric cancer, colorectal cancer, and bladder cancer. The expression status and biological function of GAPLINC in osteosarcoma are...

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Detalles Bibliográficos
Autores principales: Liao, Shian, Zhou, Sijia, Wang, Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177557/
https://www.ncbi.nlm.nih.gov/pubmed/30177521
http://dx.doi.org/10.1042/BSR20181171
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author Liao, Shian
Zhou, Sijia
Wang, Chao
author_facet Liao, Shian
Zhou, Sijia
Wang, Chao
author_sort Liao, Shian
collection PubMed
description Gastric adenocarcinoma predictive long intergenic non-coding (GAPLINC) is a novel long non-coding RNA (lncRNA) and has been found to function as an oncogenic lncRNA in gastric cancer, colorectal cancer, and bladder cancer. The expression status and biological function of GAPLINC in osteosarcoma are still unknown. Thus, we analyzed the association between GAPLINC expression and clinicopathological characteristics in osteosarcoma clinical samples, and conducted loss-of-function study in osteosarcoma cell lines. In our results, GAPLINC expression is elevated in osteosarcoma tissues and cell lines, and correlated with advanced Enneking stage, present distant metastasis, and poor histological grade. Survival analyses indicated that GAPLINC expression was negatively associated with overall survival, and GAPLINC high-expression was an independent risk factor in osteosarcoma patients. The in vitro studies showed knockdown of GAPLINC depressed osteosarcoma cell migration and invasion via inhibiting CD44 expression, but no effect on cell proliferation. In conclusion, GAPLINC may serve as a potential biomarker for predicting prognosis and developing therapy for osteosarcoma.
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spelling pubmed-61775572018-10-19 GAPLINC is a predictor of poor prognosis and regulates cell migration and invasion in osteosarcoma Liao, Shian Zhou, Sijia Wang, Chao Biosci Rep Research Articles Gastric adenocarcinoma predictive long intergenic non-coding (GAPLINC) is a novel long non-coding RNA (lncRNA) and has been found to function as an oncogenic lncRNA in gastric cancer, colorectal cancer, and bladder cancer. The expression status and biological function of GAPLINC in osteosarcoma are still unknown. Thus, we analyzed the association between GAPLINC expression and clinicopathological characteristics in osteosarcoma clinical samples, and conducted loss-of-function study in osteosarcoma cell lines. In our results, GAPLINC expression is elevated in osteosarcoma tissues and cell lines, and correlated with advanced Enneking stage, present distant metastasis, and poor histological grade. Survival analyses indicated that GAPLINC expression was negatively associated with overall survival, and GAPLINC high-expression was an independent risk factor in osteosarcoma patients. The in vitro studies showed knockdown of GAPLINC depressed osteosarcoma cell migration and invasion via inhibiting CD44 expression, but no effect on cell proliferation. In conclusion, GAPLINC may serve as a potential biomarker for predicting prognosis and developing therapy for osteosarcoma. Portland Press Ltd. 2018-10-10 /pmc/articles/PMC6177557/ /pubmed/30177521 http://dx.doi.org/10.1042/BSR20181171 Text en © 2018 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Articles
Liao, Shian
Zhou, Sijia
Wang, Chao
GAPLINC is a predictor of poor prognosis and regulates cell migration and invasion in osteosarcoma
title GAPLINC is a predictor of poor prognosis and regulates cell migration and invasion in osteosarcoma
title_full GAPLINC is a predictor of poor prognosis and regulates cell migration and invasion in osteosarcoma
title_fullStr GAPLINC is a predictor of poor prognosis and regulates cell migration and invasion in osteosarcoma
title_full_unstemmed GAPLINC is a predictor of poor prognosis and regulates cell migration and invasion in osteosarcoma
title_short GAPLINC is a predictor of poor prognosis and regulates cell migration and invasion in osteosarcoma
title_sort gaplinc is a predictor of poor prognosis and regulates cell migration and invasion in osteosarcoma
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177557/
https://www.ncbi.nlm.nih.gov/pubmed/30177521
http://dx.doi.org/10.1042/BSR20181171
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