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Gingival-derived mesenchymal stem cells: An endless resource for regenerative dentistry

The gingiva, the masticatory portion of the oral mucosa, is excised and discarded frequently during routine dental treatments and following tooth extraction, dental crown lengthening, gingivectomy and periodontal surgeries. Subsequent to excision, healing eventually happens in a short time period af...

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Autor principal: Grawish, Mohammed E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177562/
https://www.ncbi.nlm.nih.gov/pubmed/30310530
http://dx.doi.org/10.4252/wjsc.v10.i9.116
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author Grawish, Mohammed E
author_facet Grawish, Mohammed E
author_sort Grawish, Mohammed E
collection PubMed
description The gingiva, the masticatory portion of the oral mucosa, is excised and discarded frequently during routine dental treatments and following tooth extraction, dental crown lengthening, gingivectomy and periodontal surgeries. Subsequent to excision, healing eventually happens in a short time period after gingival surgery. Clinically, the gingival tissue can be collected very easily and, in the laboratory, it is also very easy to isolate gingival-derived mesenchymal stem cells (GMSCs) from this discarded gingival tissue. GMSCs, a stem cell population within the lamina propria of the gingival tissue, can be isolated from attached and free gingiva, inflamed gingival tissues, and from hyperplastic gingiva. Comparatively, they constitute more attractive alternatives to other dental-derived mesenchymal stem cells due to the availability and accessibility of gingival tissues. They have unique immunomodulatory functions and well-documented self-renewal and multipotent differentiation properties. They display positive signals for Stro-1, Oct-4 and SSEA-4 pluripotency-associated markers, with some co-expressing Oct4/Stro-1 or Oct-4/SSEA-4. They should be considered as the best stem cell source for cell-based therapies and regenerative dentistry. The clinical use of GMSCs for regenerative dentistry represents an attractive therapeutic modality. However, numerous biological and technical challenges need to be addressed prior to considering transplantation approaches of GMSCs as clinically realistic therapies for humans.
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spelling pubmed-61775622018-10-11 Gingival-derived mesenchymal stem cells: An endless resource for regenerative dentistry Grawish, Mohammed E World J Stem Cells Editorial The gingiva, the masticatory portion of the oral mucosa, is excised and discarded frequently during routine dental treatments and following tooth extraction, dental crown lengthening, gingivectomy and periodontal surgeries. Subsequent to excision, healing eventually happens in a short time period after gingival surgery. Clinically, the gingival tissue can be collected very easily and, in the laboratory, it is also very easy to isolate gingival-derived mesenchymal stem cells (GMSCs) from this discarded gingival tissue. GMSCs, a stem cell population within the lamina propria of the gingival tissue, can be isolated from attached and free gingiva, inflamed gingival tissues, and from hyperplastic gingiva. Comparatively, they constitute more attractive alternatives to other dental-derived mesenchymal stem cells due to the availability and accessibility of gingival tissues. They have unique immunomodulatory functions and well-documented self-renewal and multipotent differentiation properties. They display positive signals for Stro-1, Oct-4 and SSEA-4 pluripotency-associated markers, with some co-expressing Oct4/Stro-1 or Oct-4/SSEA-4. They should be considered as the best stem cell source for cell-based therapies and regenerative dentistry. The clinical use of GMSCs for regenerative dentistry represents an attractive therapeutic modality. However, numerous biological and technical challenges need to be addressed prior to considering transplantation approaches of GMSCs as clinically realistic therapies for humans. Baishideng Publishing Group Inc 2018-09-26 2018-09-26 /pmc/articles/PMC6177562/ /pubmed/30310530 http://dx.doi.org/10.4252/wjsc.v10.i9.116 Text en ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Editorial
Grawish, Mohammed E
Gingival-derived mesenchymal stem cells: An endless resource for regenerative dentistry
title Gingival-derived mesenchymal stem cells: An endless resource for regenerative dentistry
title_full Gingival-derived mesenchymal stem cells: An endless resource for regenerative dentistry
title_fullStr Gingival-derived mesenchymal stem cells: An endless resource for regenerative dentistry
title_full_unstemmed Gingival-derived mesenchymal stem cells: An endless resource for regenerative dentistry
title_short Gingival-derived mesenchymal stem cells: An endless resource for regenerative dentistry
title_sort gingival-derived mesenchymal stem cells: an endless resource for regenerative dentistry
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177562/
https://www.ncbi.nlm.nih.gov/pubmed/30310530
http://dx.doi.org/10.4252/wjsc.v10.i9.116
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