In vitro and in silico analysis of the effects of D (2) receptor antagonist target binding kinetics on the cellular response to fluctuating dopamine concentrations

BACKGROUND AND PURPOSE: Target binding kinetics influence the time course of the drug effect (pharmacodynamics) both (i) directly, by affecting the time course of target occupancy, driven by the pharmacokinetics of the drug, competition with endogenous ligands and target turnover, and (ii) indirectl...

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Detalles Bibliográficos
Autores principales: de Witte, Wilhelmus E A, Versfelt, Joost W, Kuzikov, Maria, Rolland, Solene, Georgi, Victoria, Gribbon, Philip, Gul, Sheraz, Huntjens, Dymphy, van der Graaf, Piet Hein, Danhof, Meindert, Fernández‐Montalván, Amaury, Witt, Gesa, de Lange, Elizabeth C M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177617/
https://www.ncbi.nlm.nih.gov/pubmed/30051456
http://dx.doi.org/10.1111/bph.14456

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177617/
https://www.ncbi.nlm.nih.gov/pubmed/30051456
http://dx.doi.org/10.1111/bph.14456

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