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A novel detection method of cleaved plasma high-molecular-weight kininogen reveals its correlation with Alzheimer's pathology and cognitive impairment
INTRODUCTION: Accumulation of β-amyloid is a pathological hallmark of Alzheimer's disease (AD). β-Amyloid activates the plasma contact system leading to kallikrein-mediated cleavage of intact high-molecular-weight kininogen (HKi) to cleaved high-molecular-weight kininogen (HKc). Increased HKi c...
Autores principales: | Yamamoto-Imoto, Hitomi, Zamolodchikov, Daria, Chen, Zu-Lin, Bourne, S. Lloyd, Rizvi, Syeda, Singh, Pradeep, Norris, Erin H., Weis-Garcia, Frances, Strickland, Sidney |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178129/ https://www.ncbi.nlm.nih.gov/pubmed/30310850 http://dx.doi.org/10.1016/j.dadm.2018.06.008 |
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