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The Ethanol Supernatant Extracts of Liushenwan Could Alleviate Nanodiethylnitrosamine-Induced Liver Cancer in Mice

Liver cancer is one of the leading causes of cancerous deaths worldwide. At present, the treatment of hepatocellular carcinoma (HCC) remains to be a problem globally. Liushenwan (LSW), an ancient Chinese medicine previously used to treat localized infections, was recently reported to possess antican...

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Autores principales: Chen, Xi-Zhen, Zhang, Wei Kevin, Tang, He-Bin, Li, Xiao-Jun, Tian, Gui-Hua, Shang, Hong-Cai, Li, Yu-Sang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178154/
https://www.ncbi.nlm.nih.gov/pubmed/30356380
http://dx.doi.org/10.1155/2018/6934809
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author Chen, Xi-Zhen
Zhang, Wei Kevin
Tang, He-Bin
Li, Xiao-Jun
Tian, Gui-Hua
Shang, Hong-Cai
Li, Yu-Sang
author_facet Chen, Xi-Zhen
Zhang, Wei Kevin
Tang, He-Bin
Li, Xiao-Jun
Tian, Gui-Hua
Shang, Hong-Cai
Li, Yu-Sang
author_sort Chen, Xi-Zhen
collection PubMed
description Liver cancer is one of the leading causes of cancerous deaths worldwide. At present, the treatment of hepatocellular carcinoma (HCC) remains to be a problem globally. Liushenwan (LSW), an ancient Chinese medicine previously used to treat localized infections, was recently reported to possess anticancer activity. Here in this study, we aim to examine the effect of LSW-ET (LSW-ET is the supernatant fraction of LSW from ultrasound assisted ethanol extraction) in prevention and treatment on nanodiethylnitrosamine- (nanoDEN-) induced HCC in mice. In nanoDEN-induced HCC mice treated with LSW-ET by oral (po) or intragastric gavage (ig), we observed an alleviation of serum ALT and AST levels, amelioration in histopathological stainings, and an inhibition in liver tumor growth. In addition, compared with the nanoDEN group, downregulation of multiple pivotal factors (COX-2, β-catenin, PCNA, and HMGB-1) was observed in LSW-ET-po and LSW-ET-ig groups. Taken together, the delivery of LSW-ET by oral could be a potential prevention and treatment of liver cancer.
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spelling pubmed-61781542018-10-23 The Ethanol Supernatant Extracts of Liushenwan Could Alleviate Nanodiethylnitrosamine-Induced Liver Cancer in Mice Chen, Xi-Zhen Zhang, Wei Kevin Tang, He-Bin Li, Xiao-Jun Tian, Gui-Hua Shang, Hong-Cai Li, Yu-Sang Can J Gastroenterol Hepatol Research Article Liver cancer is one of the leading causes of cancerous deaths worldwide. At present, the treatment of hepatocellular carcinoma (HCC) remains to be a problem globally. Liushenwan (LSW), an ancient Chinese medicine previously used to treat localized infections, was recently reported to possess anticancer activity. Here in this study, we aim to examine the effect of LSW-ET (LSW-ET is the supernatant fraction of LSW from ultrasound assisted ethanol extraction) in prevention and treatment on nanodiethylnitrosamine- (nanoDEN-) induced HCC in mice. In nanoDEN-induced HCC mice treated with LSW-ET by oral (po) or intragastric gavage (ig), we observed an alleviation of serum ALT and AST levels, amelioration in histopathological stainings, and an inhibition in liver tumor growth. In addition, compared with the nanoDEN group, downregulation of multiple pivotal factors (COX-2, β-catenin, PCNA, and HMGB-1) was observed in LSW-ET-po and LSW-ET-ig groups. Taken together, the delivery of LSW-ET by oral could be a potential prevention and treatment of liver cancer. Hindawi 2018-09-26 /pmc/articles/PMC6178154/ /pubmed/30356380 http://dx.doi.org/10.1155/2018/6934809 Text en Copyright © 2018 Xi-Zhen Chen et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chen, Xi-Zhen
Zhang, Wei Kevin
Tang, He-Bin
Li, Xiao-Jun
Tian, Gui-Hua
Shang, Hong-Cai
Li, Yu-Sang
The Ethanol Supernatant Extracts of Liushenwan Could Alleviate Nanodiethylnitrosamine-Induced Liver Cancer in Mice
title The Ethanol Supernatant Extracts of Liushenwan Could Alleviate Nanodiethylnitrosamine-Induced Liver Cancer in Mice
title_full The Ethanol Supernatant Extracts of Liushenwan Could Alleviate Nanodiethylnitrosamine-Induced Liver Cancer in Mice
title_fullStr The Ethanol Supernatant Extracts of Liushenwan Could Alleviate Nanodiethylnitrosamine-Induced Liver Cancer in Mice
title_full_unstemmed The Ethanol Supernatant Extracts of Liushenwan Could Alleviate Nanodiethylnitrosamine-Induced Liver Cancer in Mice
title_short The Ethanol Supernatant Extracts of Liushenwan Could Alleviate Nanodiethylnitrosamine-Induced Liver Cancer in Mice
title_sort ethanol supernatant extracts of liushenwan could alleviate nanodiethylnitrosamine-induced liver cancer in mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178154/
https://www.ncbi.nlm.nih.gov/pubmed/30356380
http://dx.doi.org/10.1155/2018/6934809
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