Cargando…
Reproducibility of Molecular Phenotypes after Long-Term Differentiation to Human iPSC-Derived Neurons: A Multi-Site Omics Study
Reproducibility in molecular and cellular studies is fundamental to scientific discovery. To establish the reproducibility of a well-defined long-term neuronal differentiation protocol, we repeated the cellular and molecular comparison of the same two iPSC lines across five distinct laboratories. De...
Autores principales: | Volpato, Viola, Smith, James, Sandor, Cynthia, Ried, Janina S., Baud, Anna, Handel, Adam, Newey, Sarah E., Wessely, Frank, Attar, Moustafa, Whiteley, Emma, Chintawar, Satyan, Verheyen, An, Barta, Thomas, Lako, Majlinda, Armstrong, Lyle, Muschet, Caroline, Artati, Anna, Cusulin, Carlo, Christensen, Klaus, Patsch, Christoph, Sharma, Eshita, Nicod, Jerome, Brownjohn, Philip, Stubbs, Victoria, Heywood, Wendy E., Gissen, Paul, De Filippis, Roberta, Janssen, Katharina, Reinhardt, Peter, Adamski, Jerzy, Royaux, Ines, Peeters, Pieter J., Terstappen, Georg C., Graf, Martin, Livesey, Frederick J., Akerman, Colin J., Mills, Kevin, Bowden, Rory, Nicholson, George, Webber, Caleb, Cader, M. Zameel, Lakics, Viktor |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178242/ https://www.ncbi.nlm.nih.gov/pubmed/30245212 http://dx.doi.org/10.1016/j.stemcr.2018.08.013 |
Ejemplares similares
-
Assessing similarity to primary tissue and cortical layer identity in induced pluripotent stem cell-derived cortical neurons through single-cell transcriptomics
por: Handel, Adam E., et al.
Publicado: (2016) -
A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response
por: Haenseler, Walther, et al.
Publicado: (2017) -
Targeted single-cell RNA sequencing of transcription factors enhances the identification of cell types and trajectories
por: Pokhilko, Alexandra, et al.
Publicado: (2021) -
Proteolytic shedding of the prion protein via activation of metallopeptidase ADAM10 reduces cellular binding and toxicity of amyloid-β oligomers
por: Jarosz-Griffiths, Heledd H., et al.
Publicado: (2019) -
A causal role for TRESK loss of function in migraine mechanisms
por: Pettingill, Philippa, et al.
Publicado: (2019)