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Dynamic MAPK/ERK Activity Sustains Nephron Progenitors through Niche Regulation and Primes Precursors for Differentiation

The in vivo niche and basic cellular properties of nephron progenitors are poorly described. Here we studied the cellular organization and function of the MAPK/ERK pathway in nephron progenitors. Live-imaging of ERK activity by a Förster resonance energy transfer biosensor revealed a dynamic activat...

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Detalles Bibliográficos
Autores principales:	Ihermann-Hella, Anneliis, Hirashima, Tsuyoshi, Kupari, Jussi, Kurtzeborn, Kristen, Li, Hao, Kwon, Hyuk Nam, Cebrian, Cristina, Soofi, Abdul, Dapkunas, Arvydas, Miinalainen, Ilkka, Dressler, Gregory R., Matsuda, Michiyuki, Kuure, Satu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178244/ https://www.ncbi.nlm.nih.gov/pubmed/30220628 http://dx.doi.org/10.1016/j.stemcr.2018.08.012

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