Quinolines from the cyclocondensation of isatoic anhydride with ethyl acetoacetate: preparation of ethyl 4-hydroxy-2-methylquinoline-3-carboxylate and derivatives

A convenient two-step synthesis of ethyl 4-hydroxy-2-methylquinoline-3-carboxylate derivatives has been developed starting from commercially available 2-aminobenzoic acids. In step 1, the anthranilic acids are smoothly converted to isatoic anhydrides using solid triphosgene in THF. In step 2, the an...

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Detalles Bibliográficos
Autores principales: Jentsch, Nicholas G, Hume, Jared D, Crull, Emily B, Beauti, Samer M, Pham, Amy H, Pigza, Julie A, Kessl, Jacques J, Donahue, Matthew G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2018
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178280/
https://www.ncbi.nlm.nih.gov/pubmed/30344776
http://dx.doi.org/10.3762/bjoc.14.229

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