Synthesis of dihydroquinazolines from 2-aminobenzylamine: N(3)-aryl derivatives with electron-withdrawing groups

The sequential N-functionalization of 2-aminobenzylamine (2-ABA) followed by cyclodehydration allowed for a straightforward and efficient synthesis of 3,4-dihydroquinazolines with N-aryl substituents bearing electron-withdrawing groups. The sequence involves an initial S(N)Ar displacement, N-acylati...

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Detalles Bibliográficos
Autores principales: Gruber, Nadia, Díaz, Jimena E, Orelli, Liliana R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2018
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178284/
https://www.ncbi.nlm.nih.gov/pubmed/30344774
http://dx.doi.org/10.3762/bjoc.14.227

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178284/
https://www.ncbi.nlm.nih.gov/pubmed/30344774
http://dx.doi.org/10.3762/bjoc.14.227

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