Disruption of OCT4 Ubiquitination Increases OCT4 Protein Stability and ASH2L-B-Mediated H3K4 Methylation Promoting Pluripotency Acquisition

The protein level of OCT4, a core pluripotency transcription factor, is vital for embryonic stem cell (ESC) maintenance, differentiation, and somatic cell reprogramming. However, how OCT4 protein levels are controlled during reprogramming remains largely unknown. Here, we identify ubiquitin conjugat...

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Detalles Bibliográficos
Autores principales: Li, Shuang, Xiao, Feng, Zhang, Junmei, Sun, Xiaozhi, Wang, Han, Zeng, Yanwu, Hu, Jing, Tang, Fan, Gu, Junjie, Zhao, Yingming, Jin, Ying, Liao, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178847/
https://www.ncbi.nlm.nih.gov/pubmed/30269953
http://dx.doi.org/10.1016/j.stemcr.2018.09.001

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