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Antidiabetic Biguanides Radiosensitize Hypoxic Colorectal Cancer Cells Through a Decrease in Oxygen Consumption

Background and Purpose: The anti-diabetic biguanide drugs metformin and phenformin exhibit antitumor activity in various models. However, their radiomodulatory effect under hypoxic conditions, particularly for phenformin, is largely unknown. This study therefore examines whether metformin and phenfo...

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Detalles Bibliográficos
Autores principales:	de Mey, Sven, Jiang, Heng, Corbet, Cyril, Wang, Hui, Dufait, Inès, Law, Kalun, Bastien, Estelle, Verovski, Valeri, Gevaert, Thierry, Feron, Olivier, De Ridder, Mark
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178882/ https://www.ncbi.nlm.nih.gov/pubmed/30337872 http://dx.doi.org/10.3389/fphar.2018.01073

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