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Aberrant Default Mode Network Underlying the Cognitive Deficits in the Patients With Late-Onset Depression

Late-onset depression (LOD) is regarded as a risk factor or a prodrome of Alzheimer’s disease (AD). Moreover, LOD patients with cognitive deficits have the higher risk of subsequent AD. Thus, it is necessary to understand the neural underpinnings of cognitive deficits and its pathological implicatio...

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Autores principales: Liu, Xiaoyun, Jiang, Wenhao, Yuan, Yonggui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178980/
https://www.ncbi.nlm.nih.gov/pubmed/30337869
http://dx.doi.org/10.3389/fnagi.2018.00310
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author Liu, Xiaoyun
Jiang, Wenhao
Yuan, Yonggui
author_facet Liu, Xiaoyun
Jiang, Wenhao
Yuan, Yonggui
author_sort Liu, Xiaoyun
collection PubMed
description Late-onset depression (LOD) is regarded as a risk factor or a prodrome of Alzheimer’s disease (AD). Moreover, LOD patients with cognitive deficits have the higher risk of subsequent AD. Thus, it is necessary to understand the neural underpinnings of cognitive deficits and its pathological implications in LOD. Consistent findings show that the default mode network (DMN) is an important and potentially useful brain network for the cognitive deficits in LOD patients. In recent years, genetics has been actively researched as a possible risk factor in the pathogenesis of LOD. So, in this review, we discuss the current research progress on the cognitive deficits and DMN in LOD through a combined view of brain network and genetics. We find that different structural and functional impairments of the DMN might be involved in the etiological mechanisms of different cognitive impairments in LOD patients.
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spelling pubmed-61789802018-10-18 Aberrant Default Mode Network Underlying the Cognitive Deficits in the Patients With Late-Onset Depression Liu, Xiaoyun Jiang, Wenhao Yuan, Yonggui Front Aging Neurosci Neuroscience Late-onset depression (LOD) is regarded as a risk factor or a prodrome of Alzheimer’s disease (AD). Moreover, LOD patients with cognitive deficits have the higher risk of subsequent AD. Thus, it is necessary to understand the neural underpinnings of cognitive deficits and its pathological implications in LOD. Consistent findings show that the default mode network (DMN) is an important and potentially useful brain network for the cognitive deficits in LOD patients. In recent years, genetics has been actively researched as a possible risk factor in the pathogenesis of LOD. So, in this review, we discuss the current research progress on the cognitive deficits and DMN in LOD through a combined view of brain network and genetics. We find that different structural and functional impairments of the DMN might be involved in the etiological mechanisms of different cognitive impairments in LOD patients. Frontiers Media S.A. 2018-10-03 /pmc/articles/PMC6178980/ /pubmed/30337869 http://dx.doi.org/10.3389/fnagi.2018.00310 Text en Copyright © 2018 Liu, Jiang and Yuan. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Liu, Xiaoyun
Jiang, Wenhao
Yuan, Yonggui
Aberrant Default Mode Network Underlying the Cognitive Deficits in the Patients With Late-Onset Depression
title Aberrant Default Mode Network Underlying the Cognitive Deficits in the Patients With Late-Onset Depression
title_full Aberrant Default Mode Network Underlying the Cognitive Deficits in the Patients With Late-Onset Depression
title_fullStr Aberrant Default Mode Network Underlying the Cognitive Deficits in the Patients With Late-Onset Depression
title_full_unstemmed Aberrant Default Mode Network Underlying the Cognitive Deficits in the Patients With Late-Onset Depression
title_short Aberrant Default Mode Network Underlying the Cognitive Deficits in the Patients With Late-Onset Depression
title_sort aberrant default mode network underlying the cognitive deficits in the patients with late-onset depression
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178980/
https://www.ncbi.nlm.nih.gov/pubmed/30337869
http://dx.doi.org/10.3389/fnagi.2018.00310
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