Cargando…

Discovering a new class of antifungal agents that selectively inhibits microbial carbonic anhydrases

Infections caused by pathogens resistant to the available antimicrobial treatments represent nowadays a threat to global public health. Recently, it has been demonstrated that carbonic anhydrases (CAs) are essential for the growth of many pathogens and their inhibition leads to growth defects. Princ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Annunziato, Giannamaria, Giovati, Laura, Angeli, Andrea, Pavone, Marialaura, Del Prete, Sonia, Pieroni, Marco, Capasso, Clemente, Bruno, Agostino, Conti, Stefania, Magliani, Walter, Supuran, Claudiu T., Costantino, Gabriele
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179086/ https://www.ncbi.nlm.nih.gov/pubmed/30284487 http://dx.doi.org/10.1080/14756366.2018.1516652

Ejemplares similares

An overview on the recently discovered iota-carbonic anhydrases
por: Nocentini, Alessio, et al.
Publicado: (2021)

A Highlight on the Inhibition of Fungal Carbonic Anhydrases as Drug Targets for the Antifungal Armamentarium
por: Supuran, Claudiu T., et al.
Publicado: (2021)

Bacterial ι-carbonic anhydrase: a new active class of carbonic anhydrase identified in the genome of the Gram-negative bacterium Burkholderia territorii
por: Del Prete, Sonia, et al.
Publicado: (2020)

Inhibition of bacterial α-, β- and γ-class carbonic anhydrases with selenazoles incorporating benzenesulfonamide moieties
por: Angeli, Andrea, et al.
Publicado: (2018)

Inhibition of α-, β-, γ-, δ-, ζ- and η-class carbonic anhydrases from bacteria, fungi, algae, diatoms and protozoans with famotidine
por: Angeli, Andrea, et al.
Publicado: (2019)

An Overview of the Bacterial Carbonic Anhydrases
por: Supuran, Claudiu T., et al.
Publicado: (2017)

Coumarins inhibit η-class carbonic anhydrase from Plasmodium falciparum
por: Giovannuzzi, Simone, et al.
Publicado: (2022)

Activation studies with amino acids and amines of a β-carbonic anhydrase from Mammaliicoccus (Staphylococcus) sciuri previously annotated as Staphylococcus aureus (SauBCA) carbonic anhydrase
por: Angeli, Andrea, et al.
Publicado: (2022)

Carbonic Anhydrase from Porphyromonas Gingivalis as a Drug Target
por: Supuran, Claudiu T., et al.
Publicado: (2017)

Escherichia coli γ-carbonic anhydrase: characterisation and effects of simple aromatic/heterocyclic sulphonamide inhibitors
por: Del Prete, Sonia, et al.
Publicado: (2020)

Inhibitors of O-Acetylserine Sulfhydrylase with a Cyclopropane-Carboxylic Acid Scaffold Are Effective Colistin Adjuvants in Gram Negative Bacteria
por: Annunziato, Giannamaria, et al.
Publicado: (2022)

Sulfonamide Inhibition Profile of the β-Carbonic Anhydrase from Malassezia restricta, An Opportunistic Pathogen Triggering Scalp Conditions
por: Del Prete, Sonia, et al.
Publicado: (2020)

Activation of β- and γ-carbonic anhydrases from pathogenic bacteria with tripeptides
por: Stefanucci, Azzurra, et al.
Publicado: (2018)

Synthesis, computational studies and assessment of in vitro inhibitory activity of umbelliferon-based compounds against tumour-associated carbonic anhydrase isoforms IX and XII
por: Mancuso, Francesca, et al.
Publicado: (2020)

Inhibition studies of bacterial α-carbonic anhydrases with phenols
por: Giovannuzzi, Simone, et al.
Publicado: (2022)

Anion Inhibition Profile of the β-Carbonic Anhydrase from the Opportunist Pathogenic Fungus Malassezia restricta Involved in Dandruff and Seborrheic Dermatitis
por: Prete, Sonia Del, et al.
Publicado: (2019)

Activation studies of the β-carbonic anhydrases from Malassezia restricta with amines and amino acids
por: Angeli, Andrea, et al.
Publicado: (2020)

Carbonic anhydrase IX as a novel candidate in liquid biopsy
por: Ozensoy Guler, Ozen, et al.
Publicado: (2019)

Activation Studies of the γ-Carbonic Anhydrases from the Antarctic Marine Bacteria Pseudoalteromonas haloplanktis and Colwellia psychrerythraea with Amino Acids and Amines
por: Angeli, Andrea, et al.
Publicado: (2019)

Carbonic Anhydrase Inhibitors as Novel Antibacterials in the Era of Antibiotic Resistance: Where Are We Now?
por: Nocentini, Alessio, et al.
Publicado: (2023)

4‐Sulfamoylphenylalkylamides as Inhibitors of Carbonic Anhydrases Expressed in Vibrio cholerae
por: Mancuso, Francesca, et al.
Publicado: (2021)

Crystal Structure of a Tetrameric Type II β-Carbonic Anhydrase from the Pathogenic Bacterium Burkholderia pseudomallei
por: Angeli, Andrea, et al.
Publicado: (2020)

Antibody Peptide Based Antifungal Immunotherapy
por: Magliani, Walter, et al.
Publicado: (2012)

Phaeodactylum tricornutum as a model organism for testing the membrane penetrability of sulphonamide carbonic anhydrase inhibitors
por: Rogato, Alessandra, et al.
Publicado: (2019)

The first activation study of the β-carbonic anhydrases from the pathogenic bacteria Brucella suis and Francisella tularensis with amines and amino acids
por: Angeli, Andrea, et al.
Publicado: (2019)

Microbiota, Bacterial Carbonic Anhydrases, and Modulators of Their Activity: Links to Human Diseases?
por: Amedei, Amedeo, et al.
Publicado: (2021)

Activation studies of the α- and β-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae with amines and amino acids
por: Angeli, Andrea, et al.
Publicado: (2017)

Activation studies of the β-carbonic anhydrases from Escherichia coli with amino acids and amines
por: Nocentini, Alessio, et al.
Publicado: (2020)

Phosphonamidates are the first phosphorus-based zinc binding motif to show inhibition of β-class carbonic anhydrases from bacteria, fungi, and protozoa
por: Alissa, Siham A., et al.
Publicado: (2019)

Anion Inhibition Studies of the Beta-Carbonic Anhydrase from Escherichia coli
por: Del Prete, Sonia, et al.
Publicado: (2020)

Selenocarbamates As a Prodrug‐Based Approach to Carbonic Anhydrase Inhibition
por: Angeli, Andrea, et al.
Publicado: (2022)

Activation studies with amines and amino acids of the β-carbonic anhydrase encoded by the Rv3273 gene from the pathogenic bacterium Mycobacterium tuberculosis
por: Angeli, Andrea, et al.
Publicado: (2018)

Inhibition survey with phenolic compounds against the δ- and η-class carbonic anhydrases from the marine diatom thalassiosira weissflogii and protozoan Plasmodium falciparum
por: Alissa, Siham A., et al.
Publicado: (2019)

Isatin: a privileged scaffold for the design of carbonic anhydrase inhibitors
por: Melis, Claudia, et al.
Publicado: (2016)

Activation Profile Analysis of CruCA4, an α-Carbonic Anhydrase Involved in Skeleton Formation of the Mediterranean Red Coral, Corallium rubrum
por: Del Prete, Sonia, et al.
Publicado: (2017)

Click chemistry approaches for developing carbonic anhydrase inhibitors and their applications
por: Angeli, Andrea, et al.
Publicado: (2023)

Novel thiazolone-benzenesulphonamide inhibitors of human and bacterial carbonic anhydrases
por: Abdoli, Morteza, et al.
Publicado: (2023)

The first activation study of a δ-carbonic anhydrase: TweCAδ from the diatom Thalassiosira weissflogii is effectively activated by amines and amino acids
por: Angeli, Andrea, et al.
Publicado: (2018)

Continued Structural Exploration of Sulfocoumarin as Selective Inhibitor of Tumor-Associated Human Carbonic Anhydrases IX and XII
por: Giovannuzzi, Simone, et al.
Publicado: (2022)

Synthesis, Biological and In Silico Studies of Griseofulvin and Usnic Acid Sulfonamide Derivatives as Fungal, Bacterial and Human Carbonic Anhydrase Inhibitors
por: Angeli, Andrea, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_htcks9oudj6rrcegujfn6abc1p