Thrombocytosis in a male patient with acute promyelocytic leukaemia during all-trans retinoic (ATRA) acid treatment

We present a rather uncommon side effect observed in a 20-year-old man with acute promyelocytic leukemia during treatment with ATRA. He developed a high platelet counts reaching up to 1655×10(9)/L on day 29 of ATRA treatment, and started to recover spontaneously on day 33 of treatment, without any c...

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Autores principales: Aldapt, Mahmood B., Kassem, Nancy, Al-Okka, Randa, Ghasoub, Rula, Soliman, Dina, Abdulla, Mohammad A., Mudawi, Deena, Ibrahim, Feryal, Yassin, Mohamed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mattioli 1885 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179098/
https://www.ncbi.nlm.nih.gov/pubmed/29633731
http://dx.doi.org/10.23750/abm.v89i3-S.7218
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author Aldapt, Mahmood B.
Kassem, Nancy
Al-Okka, Randa
Ghasoub, Rula
Soliman, Dina
Abdulla, Mohammad A.
Mudawi, Deena
Ibrahim, Feryal
Yassin, Mohamed A.
author_facet Aldapt, Mahmood B.
Kassem, Nancy
Al-Okka, Randa
Ghasoub, Rula
Soliman, Dina
Abdulla, Mohammad A.
Mudawi, Deena
Ibrahim, Feryal
Yassin, Mohamed A.
author_sort Aldapt, Mahmood B.
collection PubMed
description We present a rather uncommon side effect observed in a 20-year-old man with acute promyelocytic leukemia during treatment with ATRA. He developed a high platelet counts reaching up to 1655×10(9)/L on day 29 of ATRA treatment, and started to recover spontaneously on day 33 of treatment, without any change in ATRA, or adding any cytoreduction therapy. No complications associated with thrombocytosis were observed. IL-6 seems to play an important role in the pathogenesis of the thrombocytosis induced by ATRA. However, it is unclear what are the precipitating factors for this rare phenomenon and whether it is caused by certain predisposing factors that might be related to patient’s, disease pathogenesis or other unknown factors. (www.actabiomedica.it)
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spelling pubmed-61790982019-05-08 Thrombocytosis in a male patient with acute promyelocytic leukaemia during all-trans retinoic (ATRA) acid treatment Aldapt, Mahmood B. Kassem, Nancy Al-Okka, Randa Ghasoub, Rula Soliman, Dina Abdulla, Mohammad A. Mudawi, Deena Ibrahim, Feryal Yassin, Mohamed A. Acta Biomed Case Report We present a rather uncommon side effect observed in a 20-year-old man with acute promyelocytic leukemia during treatment with ATRA. He developed a high platelet counts reaching up to 1655×10(9)/L on day 29 of ATRA treatment, and started to recover spontaneously on day 33 of treatment, without any change in ATRA, or adding any cytoreduction therapy. No complications associated with thrombocytosis were observed. IL-6 seems to play an important role in the pathogenesis of the thrombocytosis induced by ATRA. However, it is unclear what are the precipitating factors for this rare phenomenon and whether it is caused by certain predisposing factors that might be related to patient’s, disease pathogenesis or other unknown factors. (www.actabiomedica.it) Mattioli 1885 2018 /pmc/articles/PMC6179098/ /pubmed/29633731 http://dx.doi.org/10.23750/abm.v89i3-S.7218 Text en Copyright: © 2018 ACTA BIO MEDICA SOCIETY OF MEDICINE AND NATURAL SCIENCES OF PARMA http://creativecommons.org/licenses/by-nc-sa/4.0 This work is licensed under a Creative Commons Attribution 4.0 International License
spellingShingle Case Report
Aldapt, Mahmood B.
Kassem, Nancy
Al-Okka, Randa
Ghasoub, Rula
Soliman, Dina
Abdulla, Mohammad A.
Mudawi, Deena
Ibrahim, Feryal
Yassin, Mohamed A.
Thrombocytosis in a male patient with acute promyelocytic leukaemia during all-trans retinoic (ATRA) acid treatment
title Thrombocytosis in a male patient with acute promyelocytic leukaemia during all-trans retinoic (ATRA) acid treatment
title_full Thrombocytosis in a male patient with acute promyelocytic leukaemia during all-trans retinoic (ATRA) acid treatment
title_fullStr Thrombocytosis in a male patient with acute promyelocytic leukaemia during all-trans retinoic (ATRA) acid treatment
title_full_unstemmed Thrombocytosis in a male patient with acute promyelocytic leukaemia during all-trans retinoic (ATRA) acid treatment
title_short Thrombocytosis in a male patient with acute promyelocytic leukaemia during all-trans retinoic (ATRA) acid treatment
title_sort thrombocytosis in a male patient with acute promyelocytic leukaemia during all-trans retinoic (atra) acid treatment
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179098/
https://www.ncbi.nlm.nih.gov/pubmed/29633731
http://dx.doi.org/10.23750/abm.v89i3-S.7218
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