αT-catenin: A developmentally dispensable, disease-linked member of the α-catenin family

α-Catenins are actin-filament binding proteins and critical subunits of the cadherin-catenin cell-cell adhesive complex. They are found in nominally-defined epithelial (E), neural (N), and testis (T) forms transcribed from three distinct genes. While most of α-catenin research has focused on the dev...

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Detalles Bibliográficos
Autores principales: Chiarella, Sergio E., Rabin, Erik E., Ostilla, Lorena A., Flozak, Annette S., Gottardi, Cara J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179130/
https://www.ncbi.nlm.nih.gov/pubmed/29746206
http://dx.doi.org/10.1080/21688370.2018.1463896
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author Chiarella, Sergio E.
Rabin, Erik E.
Ostilla, Lorena A.
Flozak, Annette S.
Gottardi, Cara J.
author_facet Chiarella, Sergio E.
Rabin, Erik E.
Ostilla, Lorena A.
Flozak, Annette S.
Gottardi, Cara J.
author_sort Chiarella, Sergio E.
collection PubMed
description α-Catenins are actin-filament binding proteins and critical subunits of the cadherin-catenin cell-cell adhesive complex. They are found in nominally-defined epithelial (E), neural (N), and testis (T) forms transcribed from three distinct genes. While most of α-catenin research has focused on the developmentally essential founding member, αE-catenin, this review discusses recent studies on αT-catenin (CTNNA3), a developmentally dispensable isoform that is emerging as relevant to cardiac, allergic and neurological diseases.
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spelling pubmed-61791302018-10-12 αT-catenin: A developmentally dispensable, disease-linked member of the α-catenin family Chiarella, Sergio E. Rabin, Erik E. Ostilla, Lorena A. Flozak, Annette S. Gottardi, Cara J. Tissue Barriers Review α-Catenins are actin-filament binding proteins and critical subunits of the cadherin-catenin cell-cell adhesive complex. They are found in nominally-defined epithelial (E), neural (N), and testis (T) forms transcribed from three distinct genes. While most of α-catenin research has focused on the developmentally essential founding member, αE-catenin, this review discusses recent studies on αT-catenin (CTNNA3), a developmentally dispensable isoform that is emerging as relevant to cardiac, allergic and neurological diseases. Taylor & Francis 2018-05-10 /pmc/articles/PMC6179130/ /pubmed/29746206 http://dx.doi.org/10.1080/21688370.2018.1463896 Text en © 2018 The Author(s). Published with license by Taylor & Francis http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Review
Chiarella, Sergio E.
Rabin, Erik E.
Ostilla, Lorena A.
Flozak, Annette S.
Gottardi, Cara J.
αT-catenin: A developmentally dispensable, disease-linked member of the α-catenin family
title αT-catenin: A developmentally dispensable, disease-linked member of the α-catenin family
title_full αT-catenin: A developmentally dispensable, disease-linked member of the α-catenin family
title_fullStr αT-catenin: A developmentally dispensable, disease-linked member of the α-catenin family
title_full_unstemmed αT-catenin: A developmentally dispensable, disease-linked member of the α-catenin family
title_short αT-catenin: A developmentally dispensable, disease-linked member of the α-catenin family
title_sort αt-catenin: a developmentally dispensable, disease-linked member of the α-catenin family
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179130/
https://www.ncbi.nlm.nih.gov/pubmed/29746206
http://dx.doi.org/10.1080/21688370.2018.1463896
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