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Adherence to chronic medication in older populations: application of a common protocol among three European cohorts
PURPOSE: The purpose of this study was to evaluate and compare medication adherence to chronic therapies in older populations across different regions in Europe. METHODS: This explorative study applied a harmonized method of data extraction and analysis from pharmacy claims databases of three Europe...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179242/ https://www.ncbi.nlm.nih.gov/pubmed/30323567 http://dx.doi.org/10.2147/PPA.S164819 |
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author | Menditto, Enrica Cahir, Caitriona Aza-Pascual-Salcedo, Mercedes Bruzzese, Dario Poblador-Plou, Beatriz Malo, Sara Costa, Elisio González-Rubio, Francisca Gimeno-Miguel, Antonio Orlando, Valentina Kardas, Przemyslaw Prados-Torres, Alexandra |
author_facet | Menditto, Enrica Cahir, Caitriona Aza-Pascual-Salcedo, Mercedes Bruzzese, Dario Poblador-Plou, Beatriz Malo, Sara Costa, Elisio González-Rubio, Francisca Gimeno-Miguel, Antonio Orlando, Valentina Kardas, Przemyslaw Prados-Torres, Alexandra |
author_sort | Menditto, Enrica |
collection | PubMed |
description | PURPOSE: The purpose of this study was to evaluate and compare medication adherence to chronic therapies in older populations across different regions in Europe. METHODS: This explorative study applied a harmonized method of data extraction and analysis from pharmacy claims databases of three European countries to compare medication adherence at a cross-country level. Data were obtained for the period between January 1, 2010, and December 31, 2011. Patients (aged ≥65 years) who newly initiated to oral antidiabetics, antihyperlipidemics, or antiosteoporotics were identified and followed for over a 12-month period. Main outcome measures were medication adherence (medication possession ratio, [MPR]; implementation) and persistence on index treatment. All country-specific data sets were prepared by employing a common data input model. Outcome measures were calculated for each country and pooled using random effect models. RESULTS: In total, 39,186 new users were analyzed. In pooled data from the three countries, suboptimal implementation (MPR <80%) was 52.45% (95% CI: 33.43–70.79) for antihy-perlipidemics, 61.35% (95% CI: 52.83–69.22) for antiosteoporotics, and 30.33% (95% CI: 25.53–35.60) for oral antidiabetics. Similarly, rates of non-persistence (discontinuation) were 55.63% (95% CI: 35.24–74.29) for antihyperlipidemics, 60.24% (95% CI: 45.35–73.46) for antiosteoporotics, and 46.80% (95% CI: 36.40–57.4) for oral antidiabetics. CONCLUSION: Medication adherence was suboptimal with >50% of older people non-adherent to antihyperlipidemics and antiosteoporotics in the three European cohorts. However, the degree of variability in adherence rates among the three countries was high. A harmonized method of data extraction and analysis across health-related database in Europe is useful to compare medication-taking behavior at a cross-country level. |
format | Online Article Text |
id | pubmed-6179242 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-61792422018-10-15 Adherence to chronic medication in older populations: application of a common protocol among three European cohorts Menditto, Enrica Cahir, Caitriona Aza-Pascual-Salcedo, Mercedes Bruzzese, Dario Poblador-Plou, Beatriz Malo, Sara Costa, Elisio González-Rubio, Francisca Gimeno-Miguel, Antonio Orlando, Valentina Kardas, Przemyslaw Prados-Torres, Alexandra Patient Prefer Adherence Original Research PURPOSE: The purpose of this study was to evaluate and compare medication adherence to chronic therapies in older populations across different regions in Europe. METHODS: This explorative study applied a harmonized method of data extraction and analysis from pharmacy claims databases of three European countries to compare medication adherence at a cross-country level. Data were obtained for the period between January 1, 2010, and December 31, 2011. Patients (aged ≥65 years) who newly initiated to oral antidiabetics, antihyperlipidemics, or antiosteoporotics were identified and followed for over a 12-month period. Main outcome measures were medication adherence (medication possession ratio, [MPR]; implementation) and persistence on index treatment. All country-specific data sets were prepared by employing a common data input model. Outcome measures were calculated for each country and pooled using random effect models. RESULTS: In total, 39,186 new users were analyzed. In pooled data from the three countries, suboptimal implementation (MPR <80%) was 52.45% (95% CI: 33.43–70.79) for antihy-perlipidemics, 61.35% (95% CI: 52.83–69.22) for antiosteoporotics, and 30.33% (95% CI: 25.53–35.60) for oral antidiabetics. Similarly, rates of non-persistence (discontinuation) were 55.63% (95% CI: 35.24–74.29) for antihyperlipidemics, 60.24% (95% CI: 45.35–73.46) for antiosteoporotics, and 46.80% (95% CI: 36.40–57.4) for oral antidiabetics. CONCLUSION: Medication adherence was suboptimal with >50% of older people non-adherent to antihyperlipidemics and antiosteoporotics in the three European cohorts. However, the degree of variability in adherence rates among the three countries was high. A harmonized method of data extraction and analysis across health-related database in Europe is useful to compare medication-taking behavior at a cross-country level. Dove Medical Press 2018-10-05 /pmc/articles/PMC6179242/ /pubmed/30323567 http://dx.doi.org/10.2147/PPA.S164819 Text en © 2018 Menditto et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Menditto, Enrica Cahir, Caitriona Aza-Pascual-Salcedo, Mercedes Bruzzese, Dario Poblador-Plou, Beatriz Malo, Sara Costa, Elisio González-Rubio, Francisca Gimeno-Miguel, Antonio Orlando, Valentina Kardas, Przemyslaw Prados-Torres, Alexandra Adherence to chronic medication in older populations: application of a common protocol among three European cohorts |
title | Adherence to chronic medication in older populations: application of a common protocol among three European cohorts |
title_full | Adherence to chronic medication in older populations: application of a common protocol among three European cohorts |
title_fullStr | Adherence to chronic medication in older populations: application of a common protocol among three European cohorts |
title_full_unstemmed | Adherence to chronic medication in older populations: application of a common protocol among three European cohorts |
title_short | Adherence to chronic medication in older populations: application of a common protocol among three European cohorts |
title_sort | adherence to chronic medication in older populations: application of a common protocol among three european cohorts |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179242/ https://www.ncbi.nlm.nih.gov/pubmed/30323567 http://dx.doi.org/10.2147/PPA.S164819 |
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