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Strength exercise weakens aerobic exercise-induced cognitive improvements in rats

Aerobic exercise improves cognitive function and adult hippocampal neurogenesis. However, the effects of aerobic exercise combined with strength exercise on cognitive function and adult hippocampal neurogenesis are still unknown. In this study, we established exercise paradigms in rats to mimic aero...

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Autores principales: Lan, Yongsheng, Huang, Zhaoyuan, Jiang, Yanjie, Zhou, Xuehua, Zhang, Jingyu, Zhang, Dianyu, Wang, Bo, Hou, Guangqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179267/
https://www.ncbi.nlm.nih.gov/pubmed/30304037
http://dx.doi.org/10.1371/journal.pone.0205562
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author Lan, Yongsheng
Huang, Zhaoyuan
Jiang, Yanjie
Zhou, Xuehua
Zhang, Jingyu
Zhang, Dianyu
Wang, Bo
Hou, Guangqing
author_facet Lan, Yongsheng
Huang, Zhaoyuan
Jiang, Yanjie
Zhou, Xuehua
Zhang, Jingyu
Zhang, Dianyu
Wang, Bo
Hou, Guangqing
author_sort Lan, Yongsheng
collection PubMed
description Aerobic exercise improves cognitive function and adult hippocampal neurogenesis. However, the effects of aerobic exercise combined with strength exercise on cognitive function and adult hippocampal neurogenesis are still unknown. In this study, we established exercise paradigms in rats to mimic aerobic exercise combined with low- and high-intensity strength exercise. We found that aerobic exercise improved spatial learning and memory as well as adult hippocampal neurogenesis, whereas strength exercise suppressed aerobic exercise-induced cognitive improvements and adult hippocampal neurogenesis in an intensity-dependent manner. Furthermore, the levels of β-hydroxybutyrate (β-HB) and its downstream effector brain-derived neurotrophic factor (BDNF) were increased in the aerobic exercise group, and strength exercise impaired the aerobic exercise-induced increases in β-HB and BDNF mRNA levels. Taken together, these results demonstrated that strength exercise weakened aerobic exercise-induced cognitive improvements and adult hippocampal neurogenesis in rats.
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spelling pubmed-61792672018-10-26 Strength exercise weakens aerobic exercise-induced cognitive improvements in rats Lan, Yongsheng Huang, Zhaoyuan Jiang, Yanjie Zhou, Xuehua Zhang, Jingyu Zhang, Dianyu Wang, Bo Hou, Guangqing PLoS One Research Article Aerobic exercise improves cognitive function and adult hippocampal neurogenesis. However, the effects of aerobic exercise combined with strength exercise on cognitive function and adult hippocampal neurogenesis are still unknown. In this study, we established exercise paradigms in rats to mimic aerobic exercise combined with low- and high-intensity strength exercise. We found that aerobic exercise improved spatial learning and memory as well as adult hippocampal neurogenesis, whereas strength exercise suppressed aerobic exercise-induced cognitive improvements and adult hippocampal neurogenesis in an intensity-dependent manner. Furthermore, the levels of β-hydroxybutyrate (β-HB) and its downstream effector brain-derived neurotrophic factor (BDNF) were increased in the aerobic exercise group, and strength exercise impaired the aerobic exercise-induced increases in β-HB and BDNF mRNA levels. Taken together, these results demonstrated that strength exercise weakened aerobic exercise-induced cognitive improvements and adult hippocampal neurogenesis in rats. Public Library of Science 2018-10-10 /pmc/articles/PMC6179267/ /pubmed/30304037 http://dx.doi.org/10.1371/journal.pone.0205562 Text en © 2018 Lan et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Lan, Yongsheng
Huang, Zhaoyuan
Jiang, Yanjie
Zhou, Xuehua
Zhang, Jingyu
Zhang, Dianyu
Wang, Bo
Hou, Guangqing
Strength exercise weakens aerobic exercise-induced cognitive improvements in rats
title Strength exercise weakens aerobic exercise-induced cognitive improvements in rats
title_full Strength exercise weakens aerobic exercise-induced cognitive improvements in rats
title_fullStr Strength exercise weakens aerobic exercise-induced cognitive improvements in rats
title_full_unstemmed Strength exercise weakens aerobic exercise-induced cognitive improvements in rats
title_short Strength exercise weakens aerobic exercise-induced cognitive improvements in rats
title_sort strength exercise weakens aerobic exercise-induced cognitive improvements in rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179267/
https://www.ncbi.nlm.nih.gov/pubmed/30304037
http://dx.doi.org/10.1371/journal.pone.0205562
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