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Strength exercise weakens aerobic exercise-induced cognitive improvements in rats
Aerobic exercise improves cognitive function and adult hippocampal neurogenesis. However, the effects of aerobic exercise combined with strength exercise on cognitive function and adult hippocampal neurogenesis are still unknown. In this study, we established exercise paradigms in rats to mimic aero...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179267/ https://www.ncbi.nlm.nih.gov/pubmed/30304037 http://dx.doi.org/10.1371/journal.pone.0205562 |
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author | Lan, Yongsheng Huang, Zhaoyuan Jiang, Yanjie Zhou, Xuehua Zhang, Jingyu Zhang, Dianyu Wang, Bo Hou, Guangqing |
author_facet | Lan, Yongsheng Huang, Zhaoyuan Jiang, Yanjie Zhou, Xuehua Zhang, Jingyu Zhang, Dianyu Wang, Bo Hou, Guangqing |
author_sort | Lan, Yongsheng |
collection | PubMed |
description | Aerobic exercise improves cognitive function and adult hippocampal neurogenesis. However, the effects of aerobic exercise combined with strength exercise on cognitive function and adult hippocampal neurogenesis are still unknown. In this study, we established exercise paradigms in rats to mimic aerobic exercise combined with low- and high-intensity strength exercise. We found that aerobic exercise improved spatial learning and memory as well as adult hippocampal neurogenesis, whereas strength exercise suppressed aerobic exercise-induced cognitive improvements and adult hippocampal neurogenesis in an intensity-dependent manner. Furthermore, the levels of β-hydroxybutyrate (β-HB) and its downstream effector brain-derived neurotrophic factor (BDNF) were increased in the aerobic exercise group, and strength exercise impaired the aerobic exercise-induced increases in β-HB and BDNF mRNA levels. Taken together, these results demonstrated that strength exercise weakened aerobic exercise-induced cognitive improvements and adult hippocampal neurogenesis in rats. |
format | Online Article Text |
id | pubmed-6179267 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-61792672018-10-26 Strength exercise weakens aerobic exercise-induced cognitive improvements in rats Lan, Yongsheng Huang, Zhaoyuan Jiang, Yanjie Zhou, Xuehua Zhang, Jingyu Zhang, Dianyu Wang, Bo Hou, Guangqing PLoS One Research Article Aerobic exercise improves cognitive function and adult hippocampal neurogenesis. However, the effects of aerobic exercise combined with strength exercise on cognitive function and adult hippocampal neurogenesis are still unknown. In this study, we established exercise paradigms in rats to mimic aerobic exercise combined with low- and high-intensity strength exercise. We found that aerobic exercise improved spatial learning and memory as well as adult hippocampal neurogenesis, whereas strength exercise suppressed aerobic exercise-induced cognitive improvements and adult hippocampal neurogenesis in an intensity-dependent manner. Furthermore, the levels of β-hydroxybutyrate (β-HB) and its downstream effector brain-derived neurotrophic factor (BDNF) were increased in the aerobic exercise group, and strength exercise impaired the aerobic exercise-induced increases in β-HB and BDNF mRNA levels. Taken together, these results demonstrated that strength exercise weakened aerobic exercise-induced cognitive improvements and adult hippocampal neurogenesis in rats. Public Library of Science 2018-10-10 /pmc/articles/PMC6179267/ /pubmed/30304037 http://dx.doi.org/10.1371/journal.pone.0205562 Text en © 2018 Lan et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Lan, Yongsheng Huang, Zhaoyuan Jiang, Yanjie Zhou, Xuehua Zhang, Jingyu Zhang, Dianyu Wang, Bo Hou, Guangqing Strength exercise weakens aerobic exercise-induced cognitive improvements in rats |
title | Strength exercise weakens aerobic exercise-induced cognitive improvements in rats |
title_full | Strength exercise weakens aerobic exercise-induced cognitive improvements in rats |
title_fullStr | Strength exercise weakens aerobic exercise-induced cognitive improvements in rats |
title_full_unstemmed | Strength exercise weakens aerobic exercise-induced cognitive improvements in rats |
title_short | Strength exercise weakens aerobic exercise-induced cognitive improvements in rats |
title_sort | strength exercise weakens aerobic exercise-induced cognitive improvements in rats |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179267/ https://www.ncbi.nlm.nih.gov/pubmed/30304037 http://dx.doi.org/10.1371/journal.pone.0205562 |
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